dap dacapo [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: dapprovided by FlyBase
Official Full Name: dacapoprovided by FlyBase
Primary source: FLYBASE:FBgn0010316
Locus tag: Dmel_CG1772
See related: AllianceGenome:FB:FBgn0010316
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: cdi4; Cdi4; CDI4; CDKN2B; CG1772; CIB1; Dac; Dacapo; dacapo/cyclin-dependent kinase interactor 4; Dap; DAP; Decapo; Dmel\CG1772; E(Sev-CycE)2B; l(2)04454; P15; p21; p21[dacapo]; p27; p27cip/kip; p27[Dap]
Summary: Enables cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in several processes, including germarium-derived oocyte fate determination; negative regulation of mitotic cell cycle; and sensory organ precursor cell division. Located in nucleus. Is expressed in several structures, including endoderm anlage; epithelium; ganglia; germline cell; and larval optic anlage. Human ortholog(s) of this gene implicated in several diseases, including Beckwith-Wiedemann syndrome; IMAGe syndrome; hematologic cancer (multiple); hyperinsulinism; and multiple endocrine neoplasia type 4. Orthologous to human CDKN1B (cyclin dependent kinase inhibitor 1B) and CDKN1C (cyclin dependent kinase inhibitor 1C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 46B1-46B1; 2-61 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (9712321..9716256)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (5599826..5603761)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proper CycE-Cdk2 activity in endocycling tissues requires regulation of the cyclin-dependent kinase inhibitor Dacapo by dE2F1b in Drosophila.
Title: Proper CycE-Cdk2 activity in endocycling tissues requires regulation of the cyclin-dependent kinase inhibitor Dacapo by dE2F1b in Drosophila.
Authors show that the cyclin-dependent kinase inhibitor Dacapo (Dap; ortholog of p57(KIP2)) determines whether NSCs enter G0 or G2 quiescence during embryogenesis.
Title: Dorsal-Ventral Differences in Neural Stem Cell Quiescence Are Induced by p57(KIP2)/Dacapo.
p27(Kip1) stabilizes the alpha-tubulin acetyltransferase 1, thereby promoting the acetylation of microtubules, a post-translational modification required for proper axonal transport.
Title: p27(Kip1) Modulates Axonal Transport by Regulating α-Tubulin Acetyltransferase 1 Stability.
in both Dicer-1 and bantam depleted genetic backgrounds, Dacapo, an inhibitor of cyclin E-Cdk complex, was found to have elevated expression.
Title: Dicer-1 regulates proliferative potential of Drosophila larval neural stem cells through bantam miRNA based down-regulation of the G1/S inhibitor Dacapo.
endo S phase-coupled destruction of Dap reduces the threshold of Cyclin E-Cdk2 activity necessary to trigger the subsequent G-S transition.
Title: Expression of an S phase-stabilized version of the CDK inhibitor Dacapo can alter endoreplication.
The Drosophila Skp2 regulates cell proliferation by targeting Dacapo for degradation.
Title: The Drosophila F-box protein dSkp2 regulates cell proliferation by targeting Dacapo for degradation.
PROSPERO provides a transient signal to ensure a precise timing for cell cycle exit of prospective neurons by activating the expression of DACAPO
Title: A transient expression of Prospero promotes cell cycle exit of Drosophila postembryonic neurons through the regulation of Dacapo.
Dap influences the timing of the mitotic/meiotic transition.
Title: The Cyclin-dependent kinase inhibitor Dacapo promotes genomic stability during premeiotic S phase.
Dcr-1 and Dap are required for nutrition-dependent cell cycle regulation in germline stem cells (GSCs) and reduction of dap partially rescues the cell cycle defect of Insulin receptor-deficient GSCs
Title: Dicer-1-dependent Dacapo suppression acts downstream of Insulin receptor in regulating cell division of Drosophila germline stem cells.
The cyclin-dependent kinase inhibitor Dacapo promotes replication licensing during Drosophila endocycles.
Title: The cyclin-dependent kinase inhibitor Dacapo promotes replication licensing during Drosophila endocycles.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in germarium-derived oocyte fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germline cell cycle switching, mitotic to meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in histoblast morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in oogenesis	TAS Traceable Author Statement more info	PubMed
involved_in premeiotic DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in sensory organ precursor cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral cord development	HMP more info	PubMed
involved_in wing disc development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info