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    CHRNB4 cholinergic receptor nicotinic beta 4 subunit [ Bos taurus (domestic cattle) ]

    Gene ID: 282181, updated on 1-Jan-2025

    Summary

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    Official Symbol
    CHRNB4provided by VGNC
    Official Full Name
    cholinergic receptor nicotinic beta 4 subunitprovided by VGNC
    Primary source
    VGNC:VGNC:27333
    See related
    BGD:BT10987; Ensembl:ENSBTAG00000003132
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CHRNB4 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (30996280..31015137, complement)

    Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit alpha 4 Neighboring gene cholinergic receptor nicotinic alpha 5 subunit Neighboring gene cholinergic receptor nicotinic alpha 3 subunit Neighboring gene ubiquitin conjugating enzyme E2 Q2 Neighboring gene F-box protein 22

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Evidence for constitutive expression of bovine adrenal a3beta4* nicotinic acetylcholine receptors. Free RB, et al. Ann N Y Acad Sci, 2002 Oct. PMID 12438106
    2. Transcription factors NF-Y and Sp1 are important determinants of the promoter activity of the bovine and human neuronal nicotinic receptor beta 4 subunit genes. Valor LM, et al. J Biol Chem, 2002 Mar 15. PMID 11742001
    3. Neuronal nicotinic acetylcholine receptors on bovine chromaffin cells: cloning, expression, and genomic organization of receptor subunits. Campos-Caro A, et al. J Neurochem, 1997 Feb. PMID 9003033
    4. An extracellular RRR motif flanking the M1 transmembrane domain governs the biogenesis of homomeric neuronal nicotinic acetylcholine receptors. Alves DS, et al. FEBS Lett, 2011 Apr 20. PMID 21420959
    5. A single neuronal nicotinic receptor alpha3alpha7beta4* is present in the bovine chromaffin cell. Maneu V, et al. Ann N Y Acad Sci, 2002 Oct. PMID 12438113

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that a basic residue at position 210 of the beta4 subunit slightly decreases alpha3beta4 receptor expression.
      Title: An extracellular RRR motif flanking the M1 transmembrane domain governs the biogenesis of homomeric neuronal nicotinic acetylcholine receptors.
    2. Bovine chromaffin cells have an alpha3alpha7beta4 nicotinic receptor
      Title: A single neuronal nicotinic receptor alpha3alpha7beta4* is present in the bovine chromaffin cell.
    3. Bovine chromaffin cells express nicotinic alpha3beta4 acetylcholine receptors
      Title: Evidence for constitutive expression of bovine adrenal a3beta4* nicotinic acetylcholine receptors.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables acetylcholine-gated monoatomic cation-selective channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuronal acetylcholine receptor subunit beta-4
    Names
    cholinergic receptor, nicotinic, beta 4 (neuronal)
    cholinergic receptor, nicotinic, beta polypeptide 4
    neuronal nicotinic receptor beta 4 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174517.2 → NP_776942.2  neuronal acetylcholine receptor subunit beta-4 precursor

      Status: VALIDATED

      Source sequence(s)
      NKLS02000021
      Related
      ENSBTAP00000048228.2, ENSBTAT00000052576.3

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      30996280..31015137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SPU6.1 GenPept UniProtKB/Swiss-Prot:Q8SPU6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials