SERPINA1 serpin family A member 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: SERPINA1provided by VGNC
Official Full Name: serpin family A member 1provided by VGNC
Primary source: VGNC:VGNC:53953
See related: BGD:BT10021; EnsemblRapid:ENSBTAG00070006145
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: PI
Orthologs: human all
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Genomic context

Location:: chromosome: 21

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	21	NC_037348.1 (59075343..59087059, complement)

Chromosome 21 - NC_037348.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comparisons of the expression patterns of cattle fetuses and their dams show that the PI gene is biallelically expressed in fetuses and predominantly monoallelically expressed in the dams.
Title: Monoallelic expression of the protease inhibitor gene in humans, sheep, and cattle.

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General gene information

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Markers

SERPINA1 (e-PCR)
- UniSTS:519324

MARC2279-2280 (e-PCR)
- UniSTS:207077

MARC_2279-2280:996678936:1 (e-PCR)
- UniSTS:207077

SERPINA1 (e-PCR)
- UniSTS:506085

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: alpha-1-antiproteinase

Names: alpha-1-antitrypsin; alpha-1-proteinase inhibitor; protease inhibitor 1 (anti-elastase, antitrypsin, alpha-1); serine (or cysteine) proteinase inhibitor, clade A (alpha-1antiproteinase, antitrypsin), member 1; serine proteinase inhibitor, clade A, member 1; serpin A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173882.2 → NP_776307.1 alpha-1-antiproteinase precursor

See identical proteins and their annotated locations for NP_776307.1

Status: PROVISIONAL

Source sequence(s)

X63129

UniProtKB/Swiss-Prot

P34955, Q3SZS3

Conserved Domains (1) summary

cd02056
Location:51 → 410

alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

Range

59075343..59087059 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005222107.3 → XP_005222164.1 alpha-1-antiproteinase isoform X1

See identical proteins and their annotated locations for XP_005222164.1

UniProtKB/Swiss-Prot

P34955, Q3SZS3

Related

ENSBTAP00070008227.1, ENSBTAT00070014047.1

Conserved Domains (1) summary

cd02056
Location:51 → 410

alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...