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    HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 503684, updated on 27-Dec-2024

    Summary

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    Official Symbol
    HMGCS2provided by VGNC
    Official Full Name
    3-hydroxy-3-methylglutaryl-CoA synthase 2provided by VGNC
    Primary source
    VGNC:VGNC:29881
    See related
    BGD:BT17324; Ensembl:ENSBTAG00000003898
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    hmgCoA
    Orthologs
    human mouse all
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    Genomic context

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    See HMGCS2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (23536604..23560576)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene regenerating family member 4 Neighboring gene uncharacterized LOC112446148 Neighboring gene phosphoglycerate dehydrogenase Neighboring gene uncharacterized LOC112445962 Neighboring gene zinc finger protein 697

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC137181

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables hydroxymethylglutaryl-CoA synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acetyl-CoA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hydroxymethylglutaryl-CoA synthase, mitochondrial
    Names
    3-hydroxy-3-methylglutaryl coenzyme A synthase
    3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
    3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)
    HMG-CoA synthase
    NP_001039348.1
    XP_010801406.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045883.1 → NP_001039348.1  hydroxymethylglutaryl-CoA synthase, mitochondrial precursor

      Status: PROVISIONAL

      Source sequence(s)
      BC112666
      UniProtKB/Swiss-Prot
      Q2KIE6
      UniProtKB/TrEMBL
      A0AAA9SSY7
      Related
      ENSBTAP00000005088.5, ENSBTAT00000005088.7
      Conserved Domains (3) summary
      TIGR01833
      Location:50 → 506
      HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
      pfam01154
      Location:53 → 223
      HMG_CoA_synt_N; Hydroxymethylglutaryl-coenzyme A synthase N terminal
      pfam08540
      Location:224 → 506
      HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      23536604..23560576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010803104.4 → XP_010801406.1  hydroxymethylglutaryl-CoA synthase, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q2KIE6
      UniProtKB/TrEMBL
      A0AAA9SSY7
      Conserved Domains (3) summary
      TIGR01833
      Location:50 → 506
      HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
      pfam01154
      Location:53 → 223
      HMG_CoA_synt_N; Hydroxymethylglutaryl-coenzyme A synthase N terminal
      pfam08540
      Location:224 → 506
      HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2KIE6.1 GenPept UniProtKB/Swiss-Prot:Q2KIE6

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