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    TM7SF2 transmembrane 7 superfamily member 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 282384, updated on 1-Jan-2025

    Summary

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    Official Symbol
    TM7SF2provided by VGNC
    Official Full Name
    transmembrane 7 superfamily member 2provided by VGNC
    Primary source
    VGNC:VGNC:35910
    See related
    BGD:BT30421; Ensembl:ENSBTAG00000005069
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See TM7SF2 in Genome Data Viewer
    Location:
    chromosome: 29
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (43317941..43322617)

    Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein like 1 Neighboring gene transmembrane protein 262 Neighboring gene VPS51 subunit of GARP complex Neighboring gene zinc finger HIT-type containing 2 Neighboring gene FAU ubiquitin like and ribosomal protein S30 fusion

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Cloning and expression of sterol Delta 14-reductase from bovine liver. Roberti R, et al. Eur J Biochem, 2002 Jan. PMID 11784322
    2. Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis. Bennati AM, et al. Biochim Biophys Acta, 2006 Jul. PMID 16784888
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC139699

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables delta14-sterol reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cholesterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    delta(14)-sterol reductase TM7SF2
    Names
    3-beta-hydroxysterol Delta (14)-reductase
    C-14 sterol reductase
    delta-14-SR
    sterol C14-reductase
    NP_777047.2
    XP_024842754.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174622.3 → NP_777047.2  delta(14)-sterol reductase TM7SF2

      See identical proteins and their annotated locations for NP_777047.2

      Status: PROVISIONAL

      Source sequence(s)
      BC118202
      UniProtKB/Swiss-Prot
      Q8WMV1
      UniProtKB/TrEMBL
      F1MQ27, Q17QS8
      Related
      ENSBTAP00000006683.3, ENSBTAT00000006683.5
      Conserved Domains (1) summary
      cl21511
      Location:9 → 418
      PEMT; Phospholipid methyltransferase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      43317941..43322617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024986986.2 → XP_024842754.1  delta(14)-sterol reductase TM7SF2 isoform X1

      UniProtKB/Swiss-Prot
      Q8WMV1
      Conserved Domains (1) summary
      cl21511
      Location:9 → 374
      PEMT; Phospholipid methyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WMV1.1 GenPept UniProtKB/Swiss-Prot:Q8WMV1

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