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    BIRC3 baculoviral IAP repeat containing 3 [ Bos taurus (domestic cattle) ]

    Gene ID: 514386, updated on 30-Jan-2025

    Summary

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    Official Symbol
    BIRC3provided by VGNC
    Official Full Name
    baculoviral IAP repeat containing 3provided by VGNC
    Primary source
    VGNC:VGNC:26500
    See related
    EnsemblRapid:ENSBTAG00070015820
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    BIRC2
    Orthologs
    human all
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    Genomic context

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    See BIRC3 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (6392612..6411566, complement)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 123 Neighboring gene baculoviral IAP repeat containing 2 Neighboring gene GTP-binding protein SAR1b-like Neighboring gene small ribosomal subunit protein eS17-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC127345

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of necroptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    baculoviral IAP repeat-containing protein 3
    Names
    baculoviral IAP repeat-containing 2
    NP_001030370.1
    XP_024830987.1
    XP_024830988.1
    XP_024830989.1
    XP_024830991.1
    XP_059730666.1
    XP_059730667.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035293.1 → NP_001030370.1  baculoviral IAP repeat-containing protein 3

      See identical proteins and their annotated locations for NP_001030370.1

      Status: PROVISIONAL

      Source sequence(s)
      BC103349
      UniProtKB/TrEMBL
      A0AAA9TC33, F1MFI1, Q3SYW8
      Related
      ENSBTAP00070020939.1, ENSBTAT00070035620.1
      Conserved Domains (5) summary
      smart00238
      Location:254 → 322
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:170 → 235
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd08329
      Location:441 → 530
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:377 → 423
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      cd16713
      Location:551 → 604
      RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      6392612..6411566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024975219.2 → XP_024830987.1  baculoviral IAP repeat-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0AAA9TC33, F1MFI1, Q3SYW8
      Conserved Domains (5) summary
      smart00238
      Location:254 → 322
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:170 → 235
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd08329
      Location:441 → 530
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:377 → 423
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      cd16713
      Location:551 → 604
      RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins

    2. XM_024975220.2 → XP_024830988.1  baculoviral IAP repeat-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0AAA9TC33, F1MFI1, Q3SYW8
      Conserved Domains (5) summary
      smart00238
      Location:254 → 322
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:170 → 235
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd08329
      Location:441 → 530
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:377 → 423
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      cd16713
      Location:551 → 604
      RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins

    3. XM_024975221.2 → XP_024830989.1  baculoviral IAP repeat-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0AAA9TC33, F1MFI1, Q3SYW8
      Conserved Domains (5) summary
      smart00238
      Location:254 → 322
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:170 → 235
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd08329
      Location:441 → 530
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:377 → 423
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      cd16713
      Location:551 → 604
      RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins

    4. XM_059874683.1 → XP_059730666.1  baculoviral IAP repeat-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0AAA9TC33, F1MFI1, Q3SYW8

    5. XM_024975223.2 → XP_024830991.1  baculoviral IAP repeat-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0AAA9TC33, F1MFI1, Q3SYW8
      Conserved Domains (5) summary
      smart00238
      Location:254 → 322
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:170 → 235
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd08329
      Location:441 → 530
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:377 → 423
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      cd16713
      Location:551 → 604
      RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins

    6. XM_059874684.1 → XP_059730667.1  baculoviral IAP repeat-containing protein 3 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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