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    DNM2 dynamin 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 511691, updated on 1-Jan-2025

    Summary

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    Official Symbol
    DNM2provided by VGNC
    Official Full Name
    dynamin 2provided by VGNC
    Primary source
    VGNC:VGNC:28143
    See related
    Ensembl:ENSBTAG00000013362
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See DNM2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (15209098..15298846)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene interleukin enhancer binding factor 3 Neighboring gene queuine tRNA-ribosyltransferase catalytic subunit 1 Neighboring gene uncharacterized LOC132345698 Neighboring gene microRNA mir-3604-1 Neighboring gene microRNA mir-199a-2 Neighboring gene chromosome 7 C19orf38 homolog Neighboring gene transmembrane p24 trafficking protein 1 Neighboring gene coactivator associated arginine methyltransferase 1 Neighboring gene Yip1 domain family member 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Dynamin-2 regulates fusion pore expansion and quantal release through a mechanism that involves actin dynamics in neuroendocrine chromaffin cells. González-Jamett AM, et al. PLoS One, 2013. PMID 23940613, Free PMC Article
    2. Mannheimia haemolytica leukotoxin binds to lipid rafts in bovine lymphoblastoid cells and is internalized in a dynamin-2- and clathrin-dependent manner. Atapattu DN, et al. Infect Immun, 2007 Oct. PMID 17682044, Free PMC Article
    3. Dynamin-2-dependent targeting of mannheimia haemolytica leukotoxin to mitochondrial cyclophilin D in bovine lymphoblastoid cells. Atapattu DN, et al. Infect Immun, 2008 Nov. PMID 18765728, Free PMC Article
    4. The proline-rich domain of dynamin-2 is responsible for dynamin-dependent in vitro potentiation of endothelial nitric-oxide synthase activity via selective effects on reductase domain function. Cao S, et al. J Biol Chem, 2003 Feb 21. PMID 12488320
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynamin-2 directs actin polymerization at the exocytosis site where both, in concert, adjust the hormone quantal release.
      Title: Dynamin-2 regulates fusion pore expansion and quantal release through a mechanism that involves actin dynamics in neuroendocrine chromaffin cells.
    2. Knocking down dynamin-2 by small interfering RNA reduced both leukotoxin internalization and cytotoxicity.
      Title: Mannheimia haemolytica leukotoxin binds to lipid rafts in bovine lymphoblastoid cells and is internalized in a dynamin-2- and clathrin-dependent manner.
    3. role of the proline-rich domain of dynamin-2 in in vitro potentiation of endothelial nitric-oxide synthase activity.
      Title: The proline-rich domain of dynamin-2 is responsible for dynamin-dependent in vitro potentiation of endothelial nitric-oxide synthase activity via selective effects on reductase domain function.
    4. LKT-mediated cell death involve dynamin-2 and cyclophilin D
      Title: Dynamin-2-dependent targeting of mannheimia haemolytica leukotoxin to mitochondrial cyclophilin D in bovine lymphoblastoid cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in synaptic vesicle endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dynamin-2
    NP_001092839.1
    XP_024849866.1
    XP_024849867.1
    XP_024849869.1
    XP_024849870.1
    XP_024849871.1
    XP_024849872.1
    XP_024849873.1
    XP_024849874.1
    XP_024849875.1
    XP_024849876.1
    XP_024849877.1
    XP_024849878.1
    XP_024849879.1
    XP_024849880.1
    XP_059744064.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099369.1 → NP_001092839.1  dynamin-2

      See identical proteins and their annotated locations for NP_001092839.1

      Status: PROVISIONAL

      Source sequence(s)
      BC146259
      UniProtKB/Swiss-Prot
      A6H7I5
      UniProtKB/TrEMBL
      F1MW91
      Related
      ENSBTAP00000035986.6, ENSBTAT00000036123.6
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      cd01256
      Location:514 → 625
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:647 → 735
      GED; Dynamin GTPase effector domain
      NF033913
      Location:698 → 861
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      15209098..15298846
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024994111.2 → XP_024849879.1  dynamin-2 isoform X12

      UniProtKB/TrEMBL
      F1MW91
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      cd01256
      Location:520 → 629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 501
      Dynamin_M; Dynamin central region
      pfam02212
      Location:651 → 739
      GED; Dynamin GTPase effector domain
      cl26464
      Location:737 → 835
      Atrophin-1; Atrophin-1 family

    2. XM_024994105.2 → XP_024849873.1  dynamin-2 isoform X7

      UniProtKB/TrEMBL
      F1MW91
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      cd01256
      Location:530 → 639
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 498
      Dynamin_M; Dynamin central region
      pfam02212
      Location:661 → 749
      GED; Dynamin GTPase effector domain
      cl26464
      Location:747 → 845
      Atrophin-1; Atrophin-1 family

    3. XM_024994110.2 → XP_024849878.1  dynamin-2 isoform X13

      UniProtKB/TrEMBL
      F1MW91
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      cd01256
      Location:520 → 629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 501
      Dynamin_M; Dynamin central region
      pfam02212
      Location:651 → 739
      GED; Dynamin GTPase effector domain
      cl26464
      Location:737 → 835
      Atrophin-1; Atrophin-1 family

    4. XM_024994099.2 → XP_024849867.1  dynamin-2 isoform X2

      UniProtKB/TrEMBL
      F1MW91
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      cd01256
      Location:530 → 639
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 498
      Dynamin_M; Dynamin central region
      pfam02212
      Location:661 → 749
      GED; Dynamin GTPase effector domain
      cl26464
      Location:749 → 876
      Atrophin-1; Atrophin-1 family

    5. XM_024994104.2 → XP_024849872.1  dynamin-2 isoform X6

      UniProtKB/TrEMBL
      F1MW91
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      cd01256
      Location:520 → 629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 501
      Dynamin_M; Dynamin central region
      pfam02212
      Location:651 → 739
      GED; Dynamin GTPase effector domain
      cl26464
      Location:739 → 866
      Atrophin-1; Atrophin-1 family

    6. XM_024994107.2 → XP_024849875.1  dynamin-2 isoform X9

      UniProtKB/TrEMBL
      F1MW91
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      cd01256
      Location:520 → 629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 501
      Dynamin_M; Dynamin central region
      pfam02212
      Location:651 → 739
      GED; Dynamin GTPase effector domain
      cl26464
      Location:747 → 866
      Atrophin-1; Atrophin-1 family

    7. XM_024994109.2 → XP_024849877.1  dynamin-2 isoform X11

      UniProtKB/TrEMBL
      F1MW91
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      cd01256
      Location:514 → 625
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 501
      Dynamin_M; Dynamin central region
      pfam02212
      Location:647 → 735
      GED; Dynamin GTPase effector domain
      cl26464
      Location:743 → 862
      Atrophin-1; Atrophin-1 family

    8. XM_024994098.2 → XP_024849866.1  dynamin-2 isoform X1

      UniProtKB/TrEMBL
      F1MW91
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      cd01256
      Location:530 → 639
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 498
      Dynamin_M; Dynamin central region
      pfam02212
      Location:661 → 749
      GED; Dynamin GTPase effector domain
      cl26464
      Location:749 → 876
      Atrophin-1; Atrophin-1 family

    9. XM_024994101.2 → XP_024849869.1  dynamin-2 isoform X3

      UniProtKB/TrEMBL
      F1MW91
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      cd01256
      Location:530 → 639
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 498
      Dynamin_M; Dynamin central region
      pfam02212
      Location:661 → 749
      GED; Dynamin GTPase effector domain
      cl26464
      Location:757 → 876
      Atrophin-1; Atrophin-1 family

    10. XM_024994102.2 → XP_024849870.1  dynamin-2 isoform X4

      UniProtKB/TrEMBL
      F1MW91
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      cd01256
      Location:524 → 635
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 498
      Dynamin_M; Dynamin central region
      pfam02212
      Location:657 → 745
      GED; Dynamin GTPase effector domain
      cl26464
      Location:745 → 872
      Atrophin-1; Atrophin-1 family

    11. XM_024994103.2 → XP_024849871.1  dynamin-2 isoform X5

      UniProtKB/TrEMBL
      F1MW91
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      cd01256
      Location:520 → 629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 501
      Dynamin_M; Dynamin central region
      pfam02212
      Location:651 → 739
      GED; Dynamin GTPase effector domain
      cl26464
      Location:739 → 866
      Atrophin-1; Atrophin-1 family

    12. XM_024994106.2 → XP_024849874.1  dynamin-2 isoform X8

      UniProtKB/TrEMBL
      F1MW91
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      cd01256
      Location:520 → 629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 501
      Dynamin_M; Dynamin central region
      pfam02212
      Location:651 → 739
      GED; Dynamin GTPase effector domain
      cl26464
      Location:739 → 865
      Atrophin-1; Atrophin-1 family

    13. XM_024994108.2 → XP_024849876.1  dynamin-2 isoform X10

      UniProtKB/TrEMBL
      F1MW91
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      cd01256
      Location:514 → 625
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 501
      Dynamin_M; Dynamin central region
      pfam02212
      Location:647 → 735
      GED; Dynamin GTPase effector domain
      cl26464
      Location:735 → 862
      Atrophin-1; Atrophin-1 family

    14. XM_024994112.2 → XP_024849880.1  dynamin-2 isoform X14

      UniProtKB/TrEMBL
      F1MW91
      Conserved Domains (5) summary
      cd08771
      Location:36 → 252
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      cd01256
      Location:488 → 597
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:174 → 456
      Dynamin_M; Dynamin central region
      pfam02212
      Location:619 → 707
      GED; Dynamin GTPase effector domain
      cl26464
      Location:707 → 834
      Atrophin-1; Atrophin-1 family

    15. XM_059888081.1 → XP_059744064.1  dynamin-2 isoform X15

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6H7I5.1 GenPept UniProtKB/Swiss-Prot:A6H7I5

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials