U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    VCP valosin containing protein [ Bos taurus (domestic cattle) ]

    Gene ID: 507345, updated on 27-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    VCPprovided by VGNC
    Official Full Name
    valosin containing proteinprovided by VGNC
    Primary source
    VGNC:VGNC:36780
    See related
    BGD:BT13330; Ensembl:ENSBTAG00000015000
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    p97
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See VCP in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (59321790..59336523, complement)

    Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132346032 Neighboring gene chromosome 8 C9orf131 homolog Neighboring gene FA complementation group G Neighboring gene phosphatidylinositol glycan anchor biosynthesis class O

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Werner syndrome protein directly binds to the AAA ATPase p97/VCP in an ATP-dependent fashion. Indig FE, et al. J Struct Biol, 2004 Apr-May. PMID 15037256
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results suggest that VCP plays a mechanistic role in releasing WRNp from the nucleolus
      Title: Werner syndrome protein directly binds to the AAA ATPase p97/VCP in an ATP-dependent fashion.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC128142

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables polyubiquitin modification-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome maturation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitotic spindle disassembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in retrograde protein transport, ER to cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of VCP-NPL4-UFD1 AAA ATPase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    transitional endoplasmic reticulum ATPase
    Names
    15S Mg(2+)-ATPase p97 subunit
    TER ATPase
    NP_001029466.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034294.2 → NP_001029466.1  transitional endoplasmic reticulum ATPase

      Status: PROVISIONAL

      Source sequence(s)
      BC103125
      UniProtKB/Swiss-Prot
      Q3ZBT1
      UniProtKB/TrEMBL
      A0A3Q1M0U9
      Related
      ENSBTAP00000019970.3, ENSBTAT00000019970.4
      Conserved Domains (6) summary
      smart01072
      Location:131 → 191
      CDC48_2; Cell division protein 48 (CDC48) domain 2
      TIGR01243
      Location:25 → 764
      CDC48; AAA family ATPase, CDC48 subfamily
      pfam00004
      Location:241 → 370
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam02359
      Location:25 → 107
      CDC48_N; Cell division protein 48 (CDC48), N-terminal domain
      pfam09336
      Location:718 → 760
      Vps4_C; Vps4 C terminal oligomerization domain
      cl21455
      Location:452 → 534
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      59321790..59336523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3ZBT1.1 GenPept UniProtKB/Swiss-Prot:Q3ZBT1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials