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    RASGEF1A RasGEF domain family member 1A [ Bos taurus (domestic cattle) ]

    Gene ID: 514877, updated on 27-Dec-2024

    Summary

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    Official Symbol
    RASGEF1Aprovided by VGNC
    Official Full Name
    RasGEF domain family member 1Aprovided by VGNC
    Primary source
    VGNC:VGNC:33743
    See related
    BGD:BT27842; Ensembl:ENSBTAG00000006870
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See RASGEF1A in Genome Data Viewer
    Location:
    chromosome: 28
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 28 NC_037355.1 (13585698..13631018, complement)

    Chromosome 28 - NC_037355.1Genomic Context describing neighboring genes Neighboring gene protein lin-28 homolog A-like Neighboring gene ret proto-oncogene Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 2 Neighboring gene uncharacterized LOC132344126 Neighboring gene FXYD domain containing ion transport regulator 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037355.1 Chromosome 28 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ras-GEF domain-containing family member 1A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015601.1 → NP_001015601.1  ras-GEF domain-containing family member 1A

      See identical proteins and their annotated locations for NP_001015601.1

      Status: PROVISIONAL

      Source sequence(s)
      BT020843
      UniProtKB/TrEMBL
      A0AAA9T9Q9, F1MYT5, Q5E9S7
      Related
      ENSBTAP00000009038.7, ENSBTAT00000009038.7
      Conserved Domains (2) summary
      cd06224
      Location:25 → 140
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:190 → 438
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037355.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      13585698..13631018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059882502.1 → XP_059738485.1  ras-GEF domain-containing family member 1A isoform X4

      UniProtKB/TrEMBL
      A0A3Q1M5Q5, A0A3Q1N010

    2. XM_059882500.1 → XP_059738483.1  ras-GEF domain-containing family member 1A isoform X2

      UniProtKB/TrEMBL
      A0AAA9T9Q9

    3. XM_059882499.1 → XP_059738482.1  ras-GEF domain-containing family member 1A isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M5Q5

    4. XM_059882501.1 → XP_059738484.1  ras-GEF domain-containing family member 1A isoform X2

      UniProtKB/TrEMBL
      A0AAA9T9Q9

    5. XM_059882503.1 → XP_059738486.1  ras-GEF domain-containing family member 1A isoform X5

    6. XM_005226256.5 → XP_005226313.1  ras-GEF domain-containing family member 1A isoform X3

      See identical proteins and their annotated locations for XP_005226313.1

      UniProtKB/TrEMBL
      A0A3Q1M5Q5
      Related
      ENSBTAP00000065647.2, ENSBTAT00000076538.2
      Conserved Domains (2) summary
      cd06224
      Location:56 → 183
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      pfam00617
      Location:224 → 418
      RasGEF; RasGEF domain
    Nucleotide Protein Strain
    Heading Accession and Version

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