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    CUL1 cullin 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 407228, updated on 1-Jan-2025

    Summary

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    Official Symbol
    CUL1provided by VGNC
    Official Full Name
    cullin 1provided by VGNC
    Primary source
    VGNC:VGNC:55747
    See related
    Ensembl:ENSBTAG00000008736
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CUL1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (111930981..112019196)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112446451 Neighboring gene thiamin pyrophosphokinase 1 Neighboring gene contactin associated protein 2 Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene uncharacterized LOC100336368 Neighboring gene enhancer of zeste 2 polycomb repressive complex 2 subunit Neighboring gene protein disulfide isomerase family A member 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Transcriptomic analysis of in vivo and in vitro produced bovine embryos revealed a developmental change in cullin 1 expression during maternal-to-embryonic transition. Kepkova KV, et al. Theriogenology, 2011 Jun. PMID 21411133
    2. Characterization of SCF-Complex during Bovine Preimplantation Development. Benesova V, et al. PLoS One, 2016. PMID 26824694, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The SCF-complex gene expression has been characterized during bovine preimplantation development.
      Title: Characterization of SCF-Complex during Bovine Preimplantation Development.
    2. Around the time of major gene activation, expression of cullin 1 switches from transcript variant 1 to transcript variant 3.
      Title: Transcriptomic analysis of in vivo and in vitro produced bovine embryos revealed a developmental change in cullin 1 expression during maternal-to-embryonic transition.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cullin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193233.1 → NP_001180162.1  cullin-1

      See identical proteins and their annotated locations for NP_001180162.1

      Status: VALIDATED

      Source sequence(s)
      DN545978, DV882578, DV885042, DY068000, EE364210, EH201830
      UniProtKB/TrEMBL
      A0A3Q1M2H6, F1MYD0
      Related
      ENSBTAP00000063991.1, ENSBTAT00000068449.1
      Conserved Domains (2) summary
      pfam00888
      Location:21 → 660
      Cullin; Cullin family
      pfam10557
      Location:706 → 767
      Cullin_Nedd8; Cullin protein neddylation domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      111930981..112019196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024990518.2 → XP_024846286.1  cullin-1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M2H6, F1MYD0
      Conserved Domains (2) summary
      pfam00888
      Location:21 → 660
      Cullin; Cullin family
      pfam10557
      Location:706 → 767
      Cullin_Nedd8; Cullin protein neddylation domain

    2. XM_059885426.1 → XP_059741409.1  cullin-1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M2H6, F1MYD0

    3. XM_059885428.1 → XP_059741411.1  cullin-1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M2H6, F1MYD0

    4. XM_059885425.1 → XP_059741408.1  cullin-1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M2H6, F1MYD0

    5. XM_059885427.1 → XP_059741410.1  cullin-1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M2H6, F1MYD0

    6. XM_024990516.2 → XP_024846284.1  cullin-1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M2H6, F1MYD0
      Conserved Domains (2) summary
      pfam00888
      Location:21 → 660
      Cullin; Cullin family
      pfam10557
      Location:706 → 767
      Cullin_Nedd8; Cullin protein neddylation domain

    7. XM_059885424.1 → XP_059741407.1  cullin-1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M2H6, F1MYD0

    8. XM_024990517.2 → XP_024846285.1  cullin-1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M2H6, F1MYD0
      Conserved Domains (2) summary
      pfam00888
      Location:21 → 660
      Cullin; Cullin family
      pfam10557
      Location:706 → 767
      Cullin_Nedd8; Cullin protein neddylation domain
    Nucleotide Protein Strain
    Heading Accession and Version

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