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    SH2D3C SH2 domain containing 3C [ Bos taurus (domestic cattle) ]

    Gene ID: 515820, updated on 27-Dec-2024

    Summary

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    Official Symbol
    SH2D3Cprovided by VGNC
    Official Full Name
    SH2 domain containing 3Cprovided by VGNC
    Primary source
    VGNC:VGNC:34559
    See related
    BGD:BT19679; Ensembl:ENSBTAG00000015375
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See SH2D3C in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (98421824..98460913, complement)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 157 Neighboring gene peptidyl-tRNA hydrolase 1 homolog Neighboring gene tetratricopeptide repeat domain 16 Neighboring gene torsin family 2 member A Neighboring gene cyclin dependent kinase 9 Neighboring gene folylpolyglutamate synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SH2 domain-containing protein 3C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098039.1 → NP_001091508.1  SH2 domain-containing protein 3C

      See identical proteins and their annotated locations for NP_001091508.1

      Status: PROVISIONAL

      Source sequence(s)
      BC140599
      UniProtKB/TrEMBL
      A0AAA9RUP3, A5D7L2
      Related
      ENSBTAP00000020433.4, ENSBTAT00000020433.6
      Conserved Domains (2) summary
      cd10337
      Location:213 → 347
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:585 → 762
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      98421824..98460913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059891226.1 → XP_059747209.1  SH2 domain-containing protein 3C isoform X1

      UniProtKB/TrEMBL
      A0AAA9RUP3, A0AAA9S081
      Related
      ENSBTAP00000076735.1, ENSBTAT00000110137.1

    2. XM_059891227.1 → XP_059747210.1  SH2 domain-containing protein 3C isoform X3

      UniProtKB/TrEMBL
      A0A3Q1LW38

    3. XM_059891230.1 → XP_059747213.1  SH2 domain-containing protein 3C isoform X3

      UniProtKB/TrEMBL
      A0A3Q1LW38
      Related
      ENSBTAP00000061408.1, ENSBTAT00000069757.2

    4. XM_005213256.5 → XP_005213313.1  SH2 domain-containing protein 3C isoform X2

      UniProtKB/TrEMBL
      A0AAA9RUP3, A0AAA9TL03
      Related
      ENSBTAP00000099125.1, ENSBTAT00000128021.1
      Conserved Domains (2) summary
      cd10337
      Location:56 → 190
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:428 → 605
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    5. XM_059891231.1 → XP_059747214.1  SH2 domain-containing protein 3C isoform X3

      UniProtKB/TrEMBL
      A0A3Q1LW38

    6. XM_059891228.1 → XP_059747211.1  SH2 domain-containing protein 3C isoform X3

      UniProtKB/TrEMBL
      A0A3Q1LW38

    7. XM_059891229.1 → XP_059747212.1  SH2 domain-containing protein 3C isoform X3

      UniProtKB/TrEMBL
      A0A3Q1LW38

    8. XM_005213257.5 → XP_005213314.1  SH2 domain-containing protein 3C isoform X3

      UniProtKB/TrEMBL
      A0A3Q1LW38
      Conserved Domains (2) summary
      cd10337
      Location:55 → 189
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:427 → 604
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    9. XM_059891232.1 → XP_059747215.1  SH2 domain-containing protein 3C isoform X4

    10. XM_059891234.1 → XP_059747217.1  SH2 domain-containing protein 3C isoform X6

    11. XM_059891233.1 → XP_059747216.1  SH2 domain-containing protein 3C isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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