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    NDUFS4 NADH:ubiquinone oxidoreductase subunit S4 [ Bos taurus (domestic cattle) ]

    Gene ID: 327680, updated on 27-Dec-2024

    Summary

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    Official Symbol
    NDUFS4provided by VGNC
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit S4provided by VGNC
    Primary source
    VGNC:VGNC:50229
    See related
    BGD:BT22556; Ensembl:ENSBTAG00000003728
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See NDUFS4 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 20 NC_037347.1 (25400369..25515962, complement)

    Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene ARF like GTPase 15 Neighboring gene uncharacterized LOC132343221 Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene uncharacterized LOC132343222 Neighboring gene follistatin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. The nuclear-encoded 18 kDa (IP) AQDQ subunit of bovine heart complex I is phosphorylated by the mitochondrial cAMP-dependent protein kinase. Papa S, et al. FEBS Lett, 1996 Feb 5. PMID 8603710
    2. Phosphorylation pattern of the NDUFS4 subunit of complex I of the mammalian respiratory chain. De Rasmo D, et al. Mitochondrion, 2010 Aug. PMID 20433953
    3. Resolution of the membrane domain of bovine complex I into subcomplexes: implications for the structural organization of the enzyme. Sazanov LA, et al. Biochemistry, 2000 Jun 20. PMID 10852722
    4. Subunit analysis of bovine heart complex I by reversed-phase high-performance liquid chromatography, electrospray ionization-tandem mass spectrometry, and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry. Lemma-Gray P, et al. Anal Biochem, 2008 Nov 15. PMID 18721790, Free PMC Article
    5. Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine heart mitochondria. Application of a novel strategy for sequencing proteins using the polymerase chain reaction. Walker JE, et al. J Mol Biol, 1992 Aug 20. PMID 1518044

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
    Names
    CI-18 kDa
    CI-AQDQ
    NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
    NADH-ubiquinone oxidoreductase 18 kDa subunit
    complex I-18 kDa
    complex I-AQDQ

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175800.2 → NP_786994.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial precursor

      See identical proteins and their annotated locations for NP_786994.1

      Status: PROVISIONAL

      Source sequence(s)
      X63215
      UniProtKB/Swiss-Prot
      Q02375
      UniProtKB/TrEMBL
      Q3T0R2
      Related
      ENSBTAP00000044670.3, ENSBTAT00000047463.5
      Conserved Domains (1) summary
      pfam04800
      Location:76 → 170
      ETC_C1_NDUFA4; ETC complex I subunit conserved region

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      25400369..25515962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024981220.2 → XP_024836988.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam04800
      Location:114 → 208
      ETC_C1_NDUFA4; ETC complex I subunit conserved region

    2. XM_024981221.2 → XP_024836989.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X2

      Conserved Domains (1) summary
      pfam04800
      Location:114 → 155
      ETC_C1_NDUFA4; ETC complex I subunit conserved region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02375.1 GenPept UniProtKB/Swiss-Prot:Q02375

    Gene LinkOut

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