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    GNAI1 G protein subunit alpha i1 [ Bos taurus (domestic cattle) ]

    Gene ID: 281790, updated on 27-Dec-2024

    Summary

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    Official Symbol
    GNAI1provided by VGNC
    Official Full Name
    G protein subunit alpha i1provided by VGNC
    Primary source
    VGNC:VGNC:29449
    See related
    BGD:BT11073; Ensembl:ENSBTAG00000002714
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    HG1B
    Orthologs
    human mouse all
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    Genomic context

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    See GNAI1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (40955829..41061583, complement)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene G protein subunit alpha transducin 3 Neighboring gene cullin-1-like Neighboring gene uncharacterized LOC100296900 Neighboring gene transcription factor BTF3-like Neighboring gene membrane associated guanylate kinase, WW and PDZ domain containing 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of cDNA encoding the GTP-binding protein alpha i and identification of a related protein, alpha h. Michel T, et al. Proc Natl Acad Sci U S A, 1986 Oct. PMID 3094012, Free PMC Article
    2. Primary structure of the alpha-subunit of bovine adenylate cyclase-inhibiting G-protein deduced from the cDNA sequence. Nukada T, et al. FEBS Lett, 1986 Mar 3. PMID 2419165
    3. NMR analysis of G-protein betagamma subunit complexes reveals a dynamic G(alpha)-Gbetagamma subunit interface and multiple protein recognition modes. Smrcka AV, et al. Proc Natl Acad Sci U S A, 2010 Jan 12. PMID 20018744, Free PMC Article
    4. Synteny mapping of five human chromosome 7 genes on bovine chromosomes 4 and 21. Antoniou E, et al. Cytogenet Cell Genet, 1999. PMID 10343125
    5. The polycystic kidney disease-1 protein, polycystin-1, binds and activates heterotrimeric G-proteins in vitro. Parnell SC, et al. Biochem Biophys Res Commun, 1998 Oct 20. PMID 9792824

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC128528

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled serotonin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of heterotrimeric G-protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(i) subunit alpha-1
    Names
    adenylate cyclase-inhibiting G alpha protein
    guanine nucleotide-binding protein G(i), alpha-1 subunit
    heterotrimeric guanine nucleotide-binding protein 1B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174324.2 → NP_776749.1  guanine nucleotide-binding protein G(i) subunit alpha-1

      See identical proteins and their annotated locations for NP_776749.1

      Status: PROVISIONAL

      Source sequence(s)
      X03642
      UniProtKB/Swiss-Prot
      P63097, Q2KJC0
      UniProtKB/TrEMBL
      A0AAA9T3M3
      Related
      ENSBTAP00000090292.1, ENSBTAT00000134892.1
      Conserved Domains (1) summary
      cd00066
      Location:34 → 348
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      40955829..41061583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005205328.5 → XP_005205385.1  guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A0AAF6YJV2
      Related
      ENSBTAP00000003515.5, ENSBTAT00000003515.6
      Conserved Domains (2) summary
      cd00066
      Location:97 → 411
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      smart00275
      Location:77 → 415
      G_alpha; G protein alpha subunit

    2. XM_015468832.3 → XP_015324318.1  guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X2

      UniProtKB/Swiss-Prot
      P63097, Q2KJC0
      UniProtKB/TrEMBL
      A0AAA9T3M3
      Conserved Domains (1) summary
      cd00066
      Location:34 → 348
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63097.2 GenPept UniProtKB/Swiss-Prot:P63097

    Gene LinkOut

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