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    AK3 adenylate kinase 3 [ Bos taurus (domestic cattle) ]

    Gene ID: 281613, updated on 1-Jan-2025

    Summary

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    Official Symbol
    AK3provided by VGNC
    Official Full Name
    adenylate kinase 3provided by VGNC
    Primary source
    VGNC:VGNC:25772
    See related
    Ensembl:ENSBTAG00000017147
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    AK3L1
    Orthologs
    human mouse all
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    Genomic context

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    See AK3 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (39797153..39819493)

    Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene RNA terminal phosphate cyclase like 1 Neighboring gene uncharacterized LOC132345947 Neighboring gene microRNA mir-101-2 Neighboring gene cell division cycle 37 like 1, HSP90 cochaperone Neighboring gene small EDRK-rich factor 2 pseudogene Neighboring gene spermatogenesis associated 6 like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. The amino acid sequence of GTP:AMP phosphotransferase from beef-heart mitochondria. Extensive homology with cytosolic adenylate kinase. Wieland B, et al. Eur J Biochem, 1984 Sep 3. PMID 6088234
    2. The complete primary structure of GTP:AMP phosphotransferase from beef heart mitochondria. Tomasselli AG, et al. FEBS Lett, 1986 Jul 7. PMID 3013690
    3. Cloning and characterization of cDNA for mitochondrial GTP:AMP phosphotransferase of bovine liver. Yamada M, et al. J Biol Chem, 1989 Nov 15. PMID 2478555
    4. Three-dimensional structure of the complex between the mitochondrial matrix adenylate kinase and its substrate AMP. Diederichs K, et al. Biochemistry, 1990 Sep 4. PMID 2175649
    5. The refined structure of the complex between adenylate kinase from beef heart mitochondrial matrix and its substrate AMP at 1.85 A resolution. Diederichs K, et al. J Mol Biol, 1991 Feb 5. PMID 1994037

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC137322

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables adenylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GTP:AMP phosphotransferase AK3, mitochondrial
    Names
    AK 3
    GTP:AMP phosphotransferase, mitochondrial
    adenylate kinase 3 alpha-like 1
    adenylate kinase 3-like 1
    adenylate kinase isozyme 3
    NP_776662.1
    XP_005210016.1
    XP_024851216.1
    XP_024851218.1
    XP_059744933.1
    XP_059744934.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174237.2 → NP_776662.1  GTP:AMP phosphotransferase AK3, mitochondrial

      See identical proteins and their annotated locations for NP_776662.1

      Status: PROVISIONAL

      Source sequence(s)
      M25757
      UniProtKB/Swiss-Prot
      P08760, Q29RI4
      Related
      ENSBTAP00000022789.3, ENSBTAT00000022789.5
      Conserved Domains (1) summary
      pfam00406
      Location:12 → 190
      ADK; Adenylate kinase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      39797153..39819493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059888951.1 → XP_059744934.1  GTP:AMP phosphotransferase AK3, mitochondrial isoform X2

    2. XM_005209959.5 → XP_005210016.1  GTP:AMP phosphotransferase AK3, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_005210016.1

      Conserved Domains (1) summary
      cl27057
      Location:1 → 120
      ADK; Adenylate kinase

    3. XM_024995450.2 → XP_024851218.1  GTP:AMP phosphotransferase AK3, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl27057
      Location:1 → 120
      ADK; Adenylate kinase

    4. XM_059888950.1 → XP_059744933.1  GTP:AMP phosphotransferase AK3, mitochondrial isoform X1

    5. XM_024995448.2 → XP_024851216.1  GTP:AMP phosphotransferase AK3, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl27057
      Location:1 → 120
      ADK; Adenylate kinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08760.3 GenPept UniProtKB/Swiss-Prot:P08760

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