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    PFKL phosphofructokinase, liver type [ Bos taurus (domestic cattle) ]

    Gene ID: 508683, updated on 30-Jan-2025

    Summary

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    Official Symbol
    PFKLprovided by VGNC
    Official Full Name
    phosphofructokinase, liver typeprovided by VGNC
    Primary source
    VGNC:VGNC:32773
    See related
    EnsemblRapid:ENSBTAG00070031871
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    PFK-L; ATP-PFK
    Orthologs
    human mouse all
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    Genomic context

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    See PFKL in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (144308777..144335971)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene DNA methyltransferase 3 like Neighboring gene autoimmune regulator Neighboring gene cilia and flagella associated protein 410 Neighboring gene transient receptor potential cation channel subfamily M member 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC142668

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 6-phosphofructokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables AMP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables fructose-6-phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables monosaccharide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in canonical glycolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in fructose 1,6-bisphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in fructose 6-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of 6-phosphofructokinase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATP-dependent 6-phosphofructokinase, liver type
    Names
    6-phosphofructokinase type B
    6-phosphofructokinase, liver type
    PFK-B
    liver-type 1-phosphofructokinase
    phosphofructo-1-kinase isozyme B
    phosphofructokinase 1
    phosphohexokinase
    NP_001073713.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080244.2 → NP_001073713.1  ATP-dependent 6-phosphofructokinase, liver type

      See identical proteins and their annotated locations for NP_001073713.1

      Status: PROVISIONAL

      Source sequence(s)
      BC126578
      UniProtKB/Swiss-Prot
      A1A4J1
      Related
      ENSBTAP00070043963.1, ENSBTAT00070072045.1
      Conserved Domains (2) summary
      cd00764
      Location:13 → 773
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
      TIGR02478
      Location:16 → 755
      6PF1K_euk; 6-phosphofructokinase, eukaryotic type

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      144308777..144335971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1A4J1.1 GenPept UniProtKB/Swiss-Prot:A1A4J1

    Gene LinkOut

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