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    MUTYH mutY DNA glycosylase [ Bos taurus (domestic cattle) ]

    Gene ID: 513051, updated on 30-Jan-2025

    Summary

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    Official Symbol
    MUTYHprovided by VGNC
    Official Full Name
    mutY DNA glycosylaseprovided by VGNC
    Primary source
    VGNC:VGNC:31765
    See related
    BGD:BT25321; EnsemblRapid:ENSBTAG00070003917
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See MUTYH in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (100722449..100731012)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene testis associated actin remodelling kinase 2 Neighboring gene BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like Neighboring gene target of EGR1, exonuclease Neighboring gene small ribosomal subunit protein eS27-like Neighboring gene 4-hydroxyphenylpyruvate dioxygenase like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC128714

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables adenine/guanine mispair binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxidized purine DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables purine-specific mismatch base pair DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in base-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mismatch repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenine DNA glycosylase
    Names
    mutY homolog
    NP_001039600.2
    XP_024843715.1
    XP_024843720.1
    XP_024843723.1
    XP_059739668.1
    XP_059739672.1
    XP_059739673.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046135.2 → NP_001039600.2  adenine DNA glycosylase

      Status: VALIDATED

      Source sequence(s)
      BC105490, CK949864, CK950215, EE342244
      UniProtKB/TrEMBL
      F1N4K4
      Conserved Domains (1) summary
      COG1194
      Location:66 → 474
      MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      100722449..100731012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059883685.1 → XP_059739668.1  adenine DNA glycosylase isoform X1

    2. XM_059883689.1 → XP_059739672.1  adenine DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0AAA9SUF4
      Related
      ENSBTAP00070005038.1, ENSBTAT00070008942.1

    3. XM_059883690.1 → XP_059739673.1  adenine DNA glycosylase isoform X3

    4. XM_024987952.2 → XP_024843720.1  adenine DNA glycosylase isoform X5

      Related
      ENSBTAP00070005039.1, ENSBTAT00070008948.1
      Conserved Domains (1) summary
      COG1194
      Location:65 → 473
      MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]

    5. XM_024987947.2 → XP_024843715.1  adenine DNA glycosylase isoform X4

      UniProtKB/TrEMBL
      F1N4K4
      Conserved Domains (1) summary
      COG1194
      Location:66 → 474
      MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]

    6. XM_024987955.2 → XP_024843723.1  adenine DNA glycosylase isoform X5

      Related
      ENSBTAP00070005036.1, ENSBTAT00070008937.1
      Conserved Domains (1) summary
      COG1194
      Location:65 → 473
      MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]
    Nucleotide Protein Strain
    Heading Accession and Version

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