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    RPA2 replication protein A2 [ Bos taurus (domestic cattle) ]

    Gene ID: 507912, updated on 1-Jan-2025

    Summary

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    Official Symbol
    RPA2provided by VGNC
    Official Full Name
    replication protein A2provided by VGNC
    Primary source
    VGNC:VGNC:34095
    See related
    BGD:BT27683
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See RPA2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (125448288..125470857)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112443407 Neighboring gene XK related 8 Neighboring gene sphingomyelin phosphodiesterase acid like 3B Neighboring gene thymocyte selection associated family member 2 Neighboring gene mitochondrial carrier homolog 1-like Neighboring gene protein phosphatase 1 regulatory subunit 8 Neighboring gene small Cajal body-specific RNA 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Purification and functional characterization of bovine RP-A in an in vitro SV40 DNA replication system. Nasheuer HP, et al. Chromosoma, 1992. PMID 1337880
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC137236

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA replication factor A complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in site of double-strand break IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    replication protein A 32 kDa subunit
    Names
    replication protein A2, 32kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045984.2 → NP_001039449.1  replication protein A 32 kDa subunit

      See identical proteins and their annotated locations for NP_001039449.1

      Status: PROVISIONAL

      Source sequence(s)
      BC112729
      UniProtKB/TrEMBL
      A0AAA9TRL7, Q2KI86
      Conserved Domains (3) summary
      COG5235
      Location:25 → 267
      RFA2; Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit [DNA replication, recombination, and repair]
      cd04478
      Location:73 → 167
      RPA2_DBD_D; RPA2_DBD_D: A subfamily of OB folds corresponding to the OB fold of the central ssDNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears ...
      pfam08784
      Location:166 → 262
      RPA_C; Replication protein A C terminal

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      125448288..125470857
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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