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    CROT carnitine O-octanoyltransferase [ Bos taurus (domestic cattle) ]

    Gene ID: 281092, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CROTprovided by VGNC
    Official Full Name
    carnitine O-octanoyltransferaseprovided by VGNC
    Primary source
    VGNC:VGNC:27723
    See related
    Ensembl:ENSBTAG00000021535
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CROT in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (33083032..33144405, complement)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene ATP-dependent translocase ABCB1 Neighboring gene ATP binding cassette subfamily B member 4 Neighboring gene nucleophosmin Neighboring gene transmembrane protein 243 Neighboring gene cyclin D binding myb like transcription factor 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning, recombinant expression, and site-directed mutagenesis of bovine liver carnitine octanoyltransferase--Arg505 binds the carboxylate group of carnitine. Cronin CN. Eur J Biochem, 1997 Aug 1. PMID 9288928
    2. Molecular cloning and expression of human carnitine octanoyltransferase: evidence for its role in the peroxisomal beta-oxidation of branched-chain fatty acids. Ferdinandusse S, et al. Biochem Biophys Res Commun, 1999 Sep 16. PMID 10486279
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC134514

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables carnitine O-octanoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peroxisomal carnitine O-octanoyltransferase
    Names
    COT
    NP_803460.1
    XP_024846207.1
    XP_024846208.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177494.2 → NP_803460.1  peroxisomal carnitine O-octanoyltransferase

      See identical proteins and their annotated locations for NP_803460.1

      Status: PROVISIONAL

      Source sequence(s)
      U65745
      UniProtKB/Swiss-Prot
      O19094
      UniProtKB/TrEMBL
      A0AAA9TJA1, A0AAF7AMD2
      Related
      ENSBTAP00000071426.2, ENSBTAT00000076118.2
      Conserved Domains (1) summary
      pfam00755
      Location:20 → 600
      Carn_acyltransf; Choline/Carnitine o-acyltransferase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      33083032..33144405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024990439.2 → XP_024846207.1  peroxisomal carnitine O-octanoyltransferase isoform X1

      UniProtKB/Swiss-Prot
      O19094
      UniProtKB/TrEMBL
      A0AAA9TJA1, A0AAF7AMD2
      Conserved Domains (1) summary
      pfam00755
      Location:20 → 600
      Carn_acyltransf; Choline/Carnitine o-acyltransferase

    2. XM_024990440.2 → XP_024846208.1  peroxisomal carnitine O-octanoyltransferase isoform X1

      UniProtKB/Swiss-Prot
      O19094
      UniProtKB/TrEMBL
      A0AAA9TJA1, A0AAF7AMD2
      Conserved Domains (1) summary
      pfam00755
      Location:20 → 600
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O19094.1 GenPept UniProtKB/Swiss-Prot:O19094

    Gene LinkOut

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