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    C4A complement component 4A [ Bos taurus (domestic cattle) ]

    Gene ID: 280678, updated on 27-Dec-2024

    Summary

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    Gene symbol
    C4A
    Gene description
    complement component 4A
    See related
    Ensembl:ENSBTAG00000037533
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    C4
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    Genomic context

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    See C4A in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (27372094..27386883, complement)

    Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene superkiller complex protein 2-like Neighboring gene complement C4-A-like Neighboring gene cytochrome P450 family 21 subfamily A member 1, pseudogene Neighboring gene serine/threonine kinase 19 Neighboring gene decapping exoribonuclease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Primary structure of bovine complement activation fragment C4a, the third anaphylatoxin. Purification and complete amino acid sequence. Smith MA, et al. Biochem J, 1982 Nov 1. PMID 6760852, Free PMC Article
    2. Increased expression of a novel splice variant of the complement component 4 (C4A) gene in mastitis-infected dairy cattle. Yang Y, et al. Genet Mol Res, 2012 Aug 29. PMID 22653646
    3. Three novel single-nucleotide polymorphisms of complement component 4 gene (C4A) in Chinese Holstein cattle and their associations with milk performance traits and CH50. Yang Y, et al. Vet Immunol Immunopathol, 2012 Jan 15. PMID 22155013
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The C4A-complete transcript is the main transcript under normal physiological conditions, while C4A-AS is augmented when mastitis develops.
      Title: Increased expression of a novel splice variant of the complement component 4 (C4A) gene in mastitis-infected dairy cattle.
    2. 3 SNPs and association with milk performance traits and CH50 assay
      Title: Three novel single-nucleotide polymorphisms of complement component 4 gene (C4A) in Chinese Holstein cattle and their associations with milk performance traits and CH50.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in complement activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    complement C4
    Names
    complement component C4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166485.1 → NP_001159957.1  complement C4 precursor

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000023
      UniProtKB/TrEMBL
      E1BH06
      Related
      ENSBTAP00000009019.7, ENSBTAT00000009019.7
      Conserved Domains (8) summary
      cd00017
      Location:684 → 753
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      cd02896
      Location:994 → 1312
      complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
      cd03584
      Location:1585 → 1739
      NTR_complement_C4; NTR/C345C domain, complement C4 subfamily; The NTR domain found in complement C4 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C4 is a key player in the activation of the component classical ...
      pfam00207
      Location:780 → 867
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:140 → 232
      A2M_N; MG2 domain
      pfam07677
      Location:1478 → 1567
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1049 → 1314
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:477 → 608
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      27372094..27386883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059880200.1 → XP_059736183.1  complement C4 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01030.2 GenPept UniProtKB/Swiss-Prot:P01030

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials