ITGB4 integrin subunit beta 4 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: ITGB4provided by VGNC
Official Full Name: integrin subunit beta 4provided by VGNC
Primary source: VGNC:VGNC:30329
See related: BGD:BT11873; Ensembl:ENSBTAG00000018169
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	19	NC_037346.1 (55840150..55872521, complement)

Chromosome 19 - NC_037346.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

integrin alpha6beta4 was indeed involved in dairy cow mammary development.
Title: Up-regulation of integrin α6β4 expression by mitogens involved in dairy cow mammary development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables integrin binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell communication	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in hemidesmosome assembly	IEA Inferred from Electronic Annotation more info	PubMed
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info	PubMed
located_in focal adhesion	IEA Inferred from Electronic Annotation more info	PubMed
part_of integrin complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: integrin beta-4

Names: integrin, beta 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001193257.2 → NP_001180186.2 integrin beta-4 precursor

Status: VALIDATED

Source sequence(s)

AAFC03054511, AAFC03117429, AAFC03129054, EH177871

UniProtKB/TrEMBL

A0AAA9S3A5

Conserved Domains (6) summary

smart00237
Location:991 → 1085

Calx_beta; Domains in Na-Ca exchangers and integrin-beta4

cd00063
Location:1221 → 1314

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:1461 → 1541

fn3; Fibronectin type III domain

pfam00362
Location:37 → 454

Integrin_beta; Integrin, beta chain

pfam07965
Location:627 → 710

Integrin_B_tail; Integrin beta tail domain

pfam07974
Location:544 → 574

EGF_2; EGF-like domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

Range

55840150..55872521 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024979798.2 → XP_024835566.1 integrin beta-4 isoform X2

UniProtKB/TrEMBL

A0AAA9S3A5

Conserved Domains (6) summary

smart00237
Location:991 → 1085

Calx_beta; Domains in Na-Ca exchangers and integrin-beta4

cd00063
Location:1458 → 1548

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07974
Location:544 → 574

EGF_2; EGF-like domain

pfam00041
Location:1572 → 1657

fn3; Fibronectin type III domain

pfam07965
Location:627 → 710

Integrin_B_tail; Integrin beta tail domain

cl00057
Location:37 → 454

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_024979797.2 → XP_024835565.1 integrin beta-4 isoform X1

UniProtKB/TrEMBL

A0A3Q1M9I5, A0AAA9S3A5

Related

ENSBTAP00000065111.1, ENSBTAT00000079531.2

Conserved Domains (6) summary

smart00237
Location:991 → 1085

Calx_beta; Domains in Na-Ca exchangers and integrin-beta4

cd00063
Location:1511 → 1601

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07974
Location:544 → 574

EGF_2; EGF-like domain

pfam00041
Location:1625 → 1710

fn3; Fibronectin type III domain

pfam07965
Location:627 → 710

Integrin_B_tail; Integrin beta tail domain

cl00057
Location:37 → 454

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_024979796.2 → XP_024835564.1 integrin beta-4 isoform X3

UniProtKB/TrEMBL

A0A3Q1MRM3, E1B864

Related

ENSBTAP00000040201.5, ENSBTAT00000042566.5

Conserved Domains (6) summary

smart00237
Location:991 → 1085

Calx_beta; Domains in Na-Ca exchangers and integrin-beta4

cd00063
Location:1521 → 1611

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07974
Location:544 → 574

EGF_2; EGF-like domain

pfam00041
Location:1635 → 1720

fn3; Fibronectin type III domain

pfam07965
Location:627 → 710

Integrin_B_tail; Integrin beta tail domain

cl00057
Location:37 → 454

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...