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    NRG1 neuregulin 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 281361, updated on 27-Dec-2024

    Summary

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    Official Symbol
    NRG1provided by VGNC
    Official Full Name
    neuregulin 1provided by VGNC
    Primary source
    VGNC:VGNC:32261
    See related
    BGD:BT25699; Ensembl:ENSBTAG00000004150
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See NRG1 in Genome Data Viewer
    Location:
    chromosome: 27
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 27 NC_037354.1 (28421153..28655095)

    Chromosome 27 - NC_037354.1Genomic Context describing neighboring genes Neighboring gene purine rich element binding protein G Neighboring gene WRN RecQ like helicase Neighboring gene uncharacterized LOC132344061 Neighboring gene transfer RNA glycine (anticodon GCC) Neighboring gene uncharacterized LOC132344062 Neighboring gene uncharacterized LOC132344092 Neighboring gene calpain small subunit 1-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system. Marchionni MA, et al. Nature, 1993 Mar 25. PMID 8096067
    2. Expression of epidermal growth factor receptors and epidermal growth factor, amphiregulin and neuregulin in bovine uteroplacental tissues during gestation. Akbalik ME, et al. Placenta, 2013 Dec. PMID 24138732
    3. A second generation radiation hybrid map to aid the assembly of the bovine genome sequence. Jann OC, et al. BMC Genomics, 2006 Nov 6. PMID 17087818, Free PMC Article
    4. Characterization of gene expression profiles in early bovine pregnancy using a custom cDNA microarray. Ishiwata H, et al. Mol Reprod Dev, 2003 May. PMID 12658628
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC154949

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables chemorepellent activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in animal organ development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pro-neuregulin-1, membrane-bound isoform

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174128.3 → NP_776553.1  pro-neuregulin-1, membrane-bound isoform

      See identical proteins and their annotated locations for NP_776553.1

      Status: VALIDATED

      Source sequence(s)
      CO884798, L12259
      UniProtKB/TrEMBL
      Q07112
      Conserved Domains (3) summary
      smart00410
      Location:43 → 129
      IG_like; Immunoglobulin like
      pfam00008
      Location:190 → 220
      EGF; EGF-like domain
      cl11960
      Location:53 → 127
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037354.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      28421153..28655095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005226079.5 → XP_005226136.1  pro-neuregulin-1, membrane-bound isoform isoform X4

      Conserved Domains (4) summary
      cd05895
      Location:53 → 127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      smart00410
      Location:43 → 129
      IG_like; Immunoglobulin like
      pfam00008
      Location:190 → 220
      EGF; EGF-like domain
      pfam02158
      Location:240 → 633
      Neuregulin; Neuregulin family

    2. XM_005226080.5 → XP_005226137.1  pro-neuregulin-1, membrane-bound isoform isoform X5

      Conserved Domains (4) summary
      cd05895
      Location:53 → 127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      smart00410
      Location:43 → 129
      IG_like; Immunoglobulin like
      pfam00008
      Location:190 → 220
      EGF; EGF-like domain
      pfam02158
      Location:235 → 628
      Neuregulin; Neuregulin family

    3. XM_005226081.5 → XP_005226138.1  pro-neuregulin-1, membrane-bound isoform isoform X6

      Conserved Domains (4) summary
      cd05895
      Location:53 → 127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      PHA03099
      Location:182 → 271
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
      smart00410
      Location:43 → 129
      IG_like; Immunoglobulin like
      pfam02158
      Location:232 → 625
      Neuregulin; Neuregulin family

    4. XM_024986179.2 → XP_024841947.1  pro-neuregulin-1, membrane-bound isoform isoform X7

      Conserved Domains (3) summary
      cd05895
      Location:53 → 127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam00008
      Location:156 → 186
      EGF; EGF-like domain
      pfam02158
      Location:206 → 599
      Neuregulin; Neuregulin family

    5. XM_024986180.2 → XP_024841948.1  pro-neuregulin-1, membrane-bound isoform isoform X8

      Conserved Domains (3) summary
      cd05895
      Location:53 → 127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam02158
      Location:198 → 591
      Neuregulin; Neuregulin family
      cl28647
      Location:124 → 237
      PHA02887; EGF-like protein; Provisional

    6. XM_005226084.5 → XP_005226141.1  pro-neuregulin-1, membrane-bound isoform isoform X12

      Conserved Domains (4) summary
      cd05895
      Location:53 → 127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      smart00410
      Location:43 → 129
      IG_like; Immunoglobulin like
      pfam00008
      Location:190 → 220
      EGF; EGF-like domain
      pfam02158
      Location:235 → 424
      Neuregulin; Neuregulin family

    7. XM_059882162.1 → XP_059738145.1  pro-neuregulin-1, membrane-bound isoform isoform X11

    8. XM_005226085.5 → XP_005226142.1  pro-neuregulin-1, membrane-bound isoform isoform X13

      Conserved Domains (4) summary
      cd05895
      Location:53 → 127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      PHA03099
      Location:182 → 271
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
      smart00410
      Location:43 → 129
      IG_like; Immunoglobulin like
      pfam02158
      Location:232 → 421
      Neuregulin; Neuregulin family

    9. XM_059882163.1 → XP_059738146.1  pro-neuregulin-1, membrane-bound isoform isoform X15

    10. XM_024986176.2 → XP_024841944.1  pro-neuregulin-1, membrane-bound isoform isoform X1

      UniProtKB/TrEMBL
      F1MPD0
      Related
      ENSBTAP00000044846.3, ENSBTAT00000047662.5
      Conserved Domains (2) summary
      pfam00008
      Location:246 → 276
      EGF; EGF-like domain
      pfam02158
      Location:296 → 689
      Neuregulin; Neuregulin family

    11. XM_024986181.2 → XP_024841949.1  pro-neuregulin-1, membrane-bound isoform isoform X9

      Conserved Domains (1) summary
      pfam02158
      Location:328 → 485
      Neuregulin; Neuregulin family

    12. XM_024986182.2 → XP_024841950.1  pro-neuregulin-1, membrane-bound isoform isoform X10

      Conserved Domains (2) summary
      PHA02887
      Location:237 → 279
      PHA02887; EGF-like protein; Provisional
      pfam02158
      Location:323 → 480
      Neuregulin; Neuregulin family

    13. XM_024986177.2 → XP_024841945.1  pro-neuregulin-1, membrane-bound isoform isoform X2

      Conserved Domains (2) summary
      pfam00008
      Location:246 → 276
      EGF; EGF-like domain
      pfam02158
      Location:291 → 684
      Neuregulin; Neuregulin family

    14. XM_024986178.2 → XP_024841946.1  pro-neuregulin-1, membrane-bound isoform isoform X3

      Conserved Domains (2) summary
      pfam00008
      Location:246 → 276
      EGF; EGF-like domain
      pfam02158
      Location:288 → 681
      Neuregulin; Neuregulin family

    15. XM_024986186.2 → XP_024841954.1  pro-neuregulin-1, membrane-bound isoform isoform X14

      Conserved Domains (1) summary
      cl28647
      Location:237 → 280
      PHA02887; EGF-like protein; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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