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    KEAP1 kelch like ECH associated protein 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 532791, updated on 1-Jan-2025

    Summary

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    Official Symbol
    KEAP1provided by VGNC
    Official Full Name
    kelch like ECH associated protein 1provided by VGNC
    Primary source
    VGNC:VGNC:30537
    See related
    BGD:BT29311; Ensembl:ENSBTAG00000003543
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See KEAP1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (15009368..15018278, complement)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 4A Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene uncharacterized LOC112447345 Neighboring gene uncharacterized LOC132345696 Neighboring gene sphingosine-1-phosphate receptor 5 Neighboring gene translation machinery-associated protein 7-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Accumulation of 15-deoxy-delta(12,14)-prostaglandin J2 adduct formation with Keap1 over time: effects on potency for intracellular antioxidant defence induction. Oh JY, et al. Biochem J, 2008 Apr 15. PMID 18237271, Free PMC Article
    2. Heat stress induces oxidative stress and activates the KEAP1-NFE2L2-ARE pathway in bovine endometrial epithelial cells†. Murata H, et al. Biol Reprod, 2021 Nov 15. PMID 34296252
    3. Escherichia coli and Staphylococcus aureus Differentially Regulate Nrf2 Pathway in Bovine Mammary Epithelial Cells: Relation to Distinct Innate Immune Response. Ying YT, et al. Cells, 2021 Dec 6. PMID 34943933, Free PMC Article
    4. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    5. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Escherichia coli and Staphylococcus aureus Differentially Regulate Nrf2 Pathway in Bovine Mammary Epithelial Cells: Relation to Distinct Innate Immune Response.
      Title: Escherichia coli and Staphylococcus aureus Differentially Regulate Nrf2 Pathway in Bovine Mammary Epithelial Cells: Relation to Distinct Innate Immune Response.
    2. Heat stress induces oxidative stress and activates the KEAP1-NFE2L2-ARE pathway in bovine endometrial epithelial cellsdagger.
      Title: Heat stress induces oxidative stress and activates the KEAP1-NFE2L2-ARE pathway in bovine endometrial epithelial cells†.
    3. the potency of 15d-PGJ2 as a signalling molecule in endothelial cells is significantly enhanced by the accumulation of the covalent adduct with 15d-PGJ2 and endogenous Keap1 over the time of exposure to the prostaglandin
      Title: Accumulation of 15-deoxy-delta(12,14)-prostaglandin J2 adduct formation with Keap1 over time: effects on potency for intracellular antioxidant defence induction.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kelch-like ECH-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101142.1 → NP_001094612.1  kelch-like ECH-associated protein 1

      See identical proteins and their annotated locations for NP_001094612.1

      Status: PROVISIONAL

      Source sequence(s)
      BC151545
      UniProtKB/TrEMBL
      A7MBG4, F1MV29
      Related
      ENSBTAP00000004604.4, ENSBTAT00000004604.5
      Conserved Domains (2) summary
      sd00038
      Location:460 → 503
      Kelch; KELCH repeat [structural motif]
      cl28614
      Location:95 → 596
      BTB; Broad-Complex, Tramtrack and Bric a brac

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      15009368..15018278 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005208764.4 → XP_005208821.1  kelch-like ECH-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005208821.1

      UniProtKB/TrEMBL
      A7MBG4, F1MV29
      Conserved Domains (2) summary
      sd00038
      Location:460 → 503
      Kelch; KELCH repeat [structural motif]
      cl28614
      Location:95 → 596
      BTB; Broad-Complex, Tramtrack and Bric a brac
    Nucleotide Protein Strain
    Heading Accession and Version

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