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    USP37 ubiquitin specific peptidase 37 [ Bos taurus (domestic cattle) ]

    Gene ID: 407168, updated on 1-Jan-2025

    Summary

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    Official Symbol
    USP37provided by VGNC
    Official Full Name
    ubiquitin specific peptidase 37provided by VGNC
    Primary source
    VGNC:VGNC:36726
    See related
    BGD:BT20469; Ensembl:ENSBTAG00000016572
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See USP37 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (106447346..106532839, complement)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene CTD small phosphatase 1 Neighboring gene microRNA mir-26b Neighboring gene villin 1 Neighboring gene CCR4-NOT transcription complex subunit 9 Neighboring gene phospholipase C delta 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 37
    Names
    deubiquitinating enzyme 37
    ubiquitin thioesterase 37
    ubiquitin thiolesterase 37
    ubiquitin-specific-processing protease 37
    NP_001258921.1
    XP_010800620.1
    XP_010800621.1
    XP_010800622.1
    XP_010800623.1
    XP_024855181.1
    XP_024855184.1
    XP_024855187.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271992.1 → NP_001258921.1  ubiquitin carboxyl-terminal hydrolase 37

      See identical proteins and their annotated locations for NP_001258921.1

      Status: VALIDATED

      Source sequence(s)
      NKLS02000002
      UniProtKB/Swiss-Prot
      F1N5V1
      UniProtKB/TrEMBL
      A0A452DJ84
      Conserved Domains (3) summary
      cd02257
      Location:864 → 951
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:344 → 608
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 104
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      106447346..106532839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024999419.2 → XP_024855187.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X2

      UniProtKB/TrEMBL
      A0A452DJ84, A0AAA9RUE4
      Related
      ENSBTAP00000075755.1, ENSBTAT00000116977.1
      Conserved Domains (3) summary
      cd02257
      Location:842 → 929
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:344 → 608
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 104
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

    2. XM_010802319.4 → XP_010800621.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

      See identical proteins and their annotated locations for XP_010800621.1

      UniProtKB/Swiss-Prot
      F1N5V1
      UniProtKB/TrEMBL
      A0A452DJ84
      Conserved Domains (3) summary
      cd02257
      Location:864 → 951
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:344 → 608
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 104
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

    3. XM_024999416.2 → XP_024855184.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

      UniProtKB/Swiss-Prot
      F1N5V1
      UniProtKB/TrEMBL
      A0A452DJ84
      Conserved Domains (3) summary
      cd02257
      Location:864 → 951
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:344 → 608
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 104
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

    4. XM_024999413.2 → XP_024855181.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

      UniProtKB/Swiss-Prot
      F1N5V1
      UniProtKB/TrEMBL
      A0A452DJ84
      Conserved Domains (3) summary
      cd02257
      Location:864 → 951
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:344 → 608
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 104
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

    5. XM_010802321.4 → XP_010800623.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X2

      UniProtKB/TrEMBL
      A0A452DJ84, A0AAA9RUE4
      Conserved Domains (3) summary
      cd02257
      Location:842 → 929
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:344 → 608
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 104
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

    6. XM_010802318.4 → XP_010800620.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

      See identical proteins and their annotated locations for XP_010800620.1

      UniProtKB/Swiss-Prot
      F1N5V1
      UniProtKB/TrEMBL
      A0A452DJ84
      Conserved Domains (3) summary
      cd02257
      Location:864 → 951
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:344 → 608
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 104
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

    7. XM_010802320.4 → XP_010800622.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

      See identical proteins and their annotated locations for XP_010800622.1

      UniProtKB/Swiss-Prot
      F1N5V1
      UniProtKB/TrEMBL
      A0A452DJ84
      Related
      ENSBTAP00000057573.1, ENSBTAT00000081874.2
      Conserved Domains (3) summary
      cd02257
      Location:864 → 951
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:344 → 608
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 104
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1N5V1.1 GenPept UniProtKB/Swiss-Prot:F1N5V1

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