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    SLC9A3 solute carrier family 9 member A3 [ Bos taurus (domestic cattle) ]

    Gene ID: 407112, updated on 1-Jan-2025

    Summary

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    Official Symbol
    SLC9A3provided by VGNC
    Official Full Name
    solute carrier family 9 member A3provided by VGNC
    Primary source
    VGNC:VGNC:34940
    See related
    BGD:BT11748; Ensembl:ENSBTAG00000004629
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See SLC9A3 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 20 NC_037347.1 (71607337..71645487)

    Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132343262 Neighboring gene tubulin polymerization promoting protein Neighboring gene centrosomal protein 72 Neighboring gene uncharacterized LOC132343263 Neighboring gene exocyst complex component 3 Neighboring gene uncharacterized LOC132343264 Neighboring gene aryl hydrocarbon receptor repressor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Evidence for NHE3-mediated Na transport in sheep and bovine forestomach. Rabbani I, et al. Am J Physiol Regul Integr Comp Physiol, 2011 Aug. PMID 21613579
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables potassium:proton antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sodium:proton antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of intracellular pH IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sodium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in brush border membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sodium/hydrogen exchanger 3
    Names
    sodium proton exchanger
    solute carrier family 9 (sodium/hydrogen exchanger), member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192154.2 → NP_001179083.1  sodium/hydrogen exchanger 3 precursor

      Status: VALIDATED

      Source sequence(s)
      NKLS02000020
      UniProtKB/TrEMBL
      A0AAA9U035, F1MU00
      Related
      ENSBTAP00000006073.4, ENSBTAT00000006073.6
      Conserved Domains (3) summary
      TIGR00840
      Location:50 → 649
      b_cpa1; sodium/hydrogen exchanger 3
      pfam00999
      Location:107 → 464
      Na_H_Exchanger; Sodium/hydrogen exchanger family
      pfam16644
      Location:607 → 671
      NEXCaM_BD; Regulatory region of Na+/H+ exchanger NHE binds to calmodulin

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      71607337..71645487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059878675.1 → XP_059734658.1  sodium/hydrogen exchanger 3 isoform X1

      UniProtKB/TrEMBL
      A0AAA9U035
      Related
      ENSBTAP00000103230.1, ENSBTAT00000113566.1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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