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    USP15 ubiquitin specific peptidase 15 [ Bos taurus (domestic cattle) ]

    Gene ID: 538284, updated on 1-Jan-2025

    Summary

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    Official Symbol
    USP15provided by VGNC
    Official Full Name
    ubiquitin specific peptidase 15provided by VGNC
    Primary source
    VGNC:VGNC:36713
    See related
    BGD:BT16214; Ensembl:ENSBTAG00000010428
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Annotation information
    Note: GeneIDs 538284 and 100851705 are annotated as adjacent genes in Btau_4.6.1, but may be redundant. [17 Jun 2014]
    Orthologs
    human mouse all
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    Genomic context

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    See USP15 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (51147112..51275743, complement)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase 2-like Neighboring gene uncharacterized LOC132345293 Neighboring gene microRNA let-7i Neighboring gene MON2 homolog, regulator of endosome-to-Golgi trafficking Neighboring gene TAFA chemokine like family member 2 Neighboring gene sentrin-specific protease 8-like Neighboring gene histone H2B type 2-E-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC128893

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 15
    Names
    deubiquitinating enzyme 15
    ubiquitin thioesterase 15
    ubiquitin-specific-processing protease 15
    NP_001039895.1
    XP_003586137.1
    XP_005206775.1
    XP_024847741.1
    XP_059742566.1
    XP_059742567.1
    XP_059742568.1
    XP_059742569.1
    XP_059742570.1
    XP_059742571.1
    XP_059742572.1
    XP_059742573.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046430.2 → NP_001039895.1  ubiquitin carboxyl-terminal hydrolase 15

      See identical proteins and their annotated locations for NP_001039895.1

      Status: VALIDATED

      Source sequence(s)
      BC105521, DT860170, NKLS02000005
      UniProtKB/Swiss-Prot
      Q2HJE4
      Related
      ENSBTAP00000056662.1, ENSBTAT00000078328.1
      Conserved Domains (1) summary
      cl02553
      Location:12 → 903
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      51147112..51275743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003586089.6 → XP_003586137.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X1

      See identical proteins and their annotated locations for XP_003586137.1

      UniProtKB/TrEMBL
      A0A3Q1M4Y9
      Related
      ENSBTAP00000064906.1, ENSBTAT00000086414.2
      Conserved Domains (6) summary
      smart00695
      Location:24 → 121
      DUSP; Domain in ubiquitin-specific proteases
      COG5560
      Location:12 → 932
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02674
      Location:784 → 931
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:290 → 474
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam14533
      Location:470 → 597
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam14836
      Location:135 → 222
      Ubiquitin_3; Ubiquitin-like domain

    2. XM_059886584.1 → XP_059742567.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X3

    3. XM_059886583.1 → XP_059742566.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X2

    4. XM_059886588.1 → XP_059742571.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X7

    5. XM_059886587.1 → XP_059742570.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X6

    6. XM_059886586.1 → XP_059742569.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X5

    7. XM_059886589.1 → XP_059742572.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X7

    8. XM_059886590.1 → XP_059742573.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X8

    9. XM_059886585.1 → XP_059742568.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X4

    10. XM_024991973.2 → XP_024847741.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X9

      Conserved Domains (1) summary
      cl02553
      Location:12 → 492
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    11. XM_005206718.5 → XP_005206775.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X10

      See identical proteins and their annotated locations for XP_005206775.1

      UniProtKB/TrEMBL
      A0AAA9S847
      Related
      ENSBTAP00000078328.1, ENSBTAT00000113449.1
      Conserved Domains (2) summary
      smart00695
      Location:24 → 121
      DUSP; Domain in ubiquitin-specific proteases
      pfam14836
      Location:135 → 222
      Ubiquitin_3; Ubiquitin-like domain

    RNA

    1. XR_003034598.2 RNA Sequence

    2. XR_009494417.1 RNA Sequence

    3. XR_009494418.1 RNA Sequence

    4. XR_009494416.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2HJE4.1 GenPept UniProtKB/Swiss-Prot:Q2HJE4

    Gene LinkOut

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