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    SPAST spastin [ Bos taurus (domestic cattle) ]

    Gene ID: 521442, updated on 30-Jan-2025

    Summary

    Official Symbol
    SPASTprovided by VGNC
    Official Full Name
    spastinprovided by VGNC
    Primary source
    VGNC:VGNC:35174
    See related
    EnsemblRapid:ENSBTAG00070010616
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    SPG4
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SPAST in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (14696373..14753291)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL42-like Neighboring gene mediator of cell motility 1 Neighboring gene transmembrane protein 33-like Neighboring gene dpy-30 histone methyltransferase complex regulatory subunit Neighboring gene solute carrier family 30 member 6 Neighboring gene uncharacterized LOC132346550 Neighboring gene NLR family CARD domain containing 4

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Expression

    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    General protein information

    Preferred Names
    spastin
    NP_001075060.1
    XP_005212586.1
    XP_005212587.1
    XP_024854478.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081591.1NP_001075060.1  spastin

      See identical proteins and their annotated locations for NP_001075060.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133327
      UniProtKB/Swiss-Prot
      A2VDN5
      UniProtKB/TrEMBL
      A0A3Q1MRP0
      Related
      ENSBTAP00070014133.1, ENSBTAT00070023823.1
      Conserved Domains (5) summary
      smart00382
      Location:372508
      AAA; ATPases associated with a variety of cellular activities
      cd02679
      Location:114193
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
      pfam00004
      Location:376506
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:578610
      Vps4_C; Vps4 C terminal oligomerization domain
      cl21455
      Location:339395
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      14696373..14753291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005212530.4XP_005212587.1  spastin isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MNP4, A0AAF6ZVI0
      Related
      ENSBTAP00070014141.1, ENSBTAT00070023835.1
      Conserved Domains (5) summary
      smart00382
      Location:340476
      AAA; ATPases associated with a variety of cellular activities
      cd02679
      Location:114193
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
      pfam00004
      Location:344474
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:546578
      Vps4_C; Vps4 C terminal oligomerization domain
      cl21455
      Location:307363
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. XM_005212529.4XP_005212586.1  spastin isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MRP0
      Conserved Domains (5) summary
      smart00382
      Location:371507
      AAA; ATPases associated with a variety of cellular activities
      cd02679
      Location:114192
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
      pfam00004
      Location:375505
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:577609
      Vps4_C; Vps4 C terminal oligomerization domain
      cl21455
      Location:338394
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. XM_024998710.2XP_024854478.1  spastin isoform X3

      UniProtKB/TrEMBL
      A0A3Q1MNP4
      Conserved Domains (2) summary
      COG0464
      Location:271562
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
      cd02679
      Location:114192
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...