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    ASPA aspartoacylase [ Bos taurus (domestic cattle) ]

    Gene ID: 509432, updated on 30-Jan-2025

    Summary

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    Official Symbol
    ASPAprovided by VGNC
    Official Full Name
    aspartoacylaseprovided by VGNC
    Primary source
    VGNC:VGNC:26217
    See related
    EnsemblRapid:ENSBTAG00070018612
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    ASP
    Orthologs
    human mouse all
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    Genomic context

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    See ASPA in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (24214191..24235467)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 1 subfamily E member 1 Neighboring gene spermatogenesis associated 22 Neighboring gene transient receptor potential cation channel subfamily V member 3 Neighboring gene transient receptor potential cation channel subfamily V member 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Canavan disease: genomic organization and localization of human ASPA to 17p13-ter and conservation of the ASPA gene during evolution. Kaul R, et al. Genomics, 1994 May 15. PMID 8088831
    2. Cloning of the human aspartoacylase cDNA and a common missense mutation in Canavan disease. Kaul R, et al. Nat Genet, 1993 Oct. PMID 8252036
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC137381

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aspartoacylase
    Names
    ACY-2
    aminoacylase 2
    aspartoacylase (Canavan disease)
    NP_001039498.1
    XP_005220265.1
    XP_010814208.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046033.2 → NP_001039498.1  aspartoacylase

      See identical proteins and their annotated locations for NP_001039498.1

      Status: PROVISIONAL

      Source sequence(s)
      BC112799
      UniProtKB/Swiss-Prot
      P46446
      UniProtKB/TrEMBL
      Q2KI21
      Conserved Domains (2) summary
      cd06909
      Location:12 → 291
      M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
      pfam04952
      Location:10 → 291
      AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      24214191..24235467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010815906.3 → XP_010814208.1  aspartoacylase isoform X1

      See identical proteins and their annotated locations for XP_010814208.1

      UniProtKB/Swiss-Prot
      P46446
      UniProtKB/TrEMBL
      F1MUZ8
      Related
      ENSBTAP00070025085.1, ENSBTAT00070042061.1
      Conserved Domains (2) summary
      cd06909
      Location:12 → 300
      M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
      pfam04952
      Location:10 → 300
      AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family

    2. XM_005220208.4 → XP_005220265.1  aspartoacylase isoform X1

      See identical proteins and their annotated locations for XP_005220265.1

      UniProtKB/Swiss-Prot
      P46446
      UniProtKB/TrEMBL
      F1MUZ8
      Conserved Domains (2) summary
      cd06909
      Location:12 → 300
      M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
      pfam04952
      Location:10 → 300
      AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46446.1 GenPept UniProtKB/Swiss-Prot:P46446

    Gene LinkOut

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