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    CHN2 chimerin 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 507285, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CHN2provided by VGNC
    Official Full Name
    chimerin 2provided by VGNC
    Primary source
    VGNC:VGNC:50060
    See related
    Ensembl:ENSBTAG00000020931
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CHN2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (66633619..66970916, complement)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene WAS/WASL interacting protein family member 3 Neighboring gene major facilitator superfamily domain-containing protein 1-like Neighboring gene uncharacterized LOC132345108 Neighboring gene proline rich 15 Neighboring gene uncharacterized LOC132345109 Neighboring gene carboxypeptidase vitellogenic like Neighboring gene TLR4 interactor with leucine rich repeats

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC137510

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-chimaerin
    Names
    chimerin (chimaerin) 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045963.2 → NP_001039428.1  beta-chimaerin

      See identical proteins and their annotated locations for NP_001039428.1

      Status: PROVISIONAL

      Source sequence(s)
      BC114099
      UniProtKB/TrEMBL
      Q29RN4
      Conserved Domains (2) summary
      cd04372
      Location:139 → 332
      RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
      pfam00130
      Location:79 → 131
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      66633619..66970916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005205489.3 → XP_005205546.1  beta-chimaerin isoform X1

      See identical proteins and their annotated locations for XP_005205546.1

      UniProtKB/TrEMBL
      A0AAA9S6U0, E1BEJ8, Q0VD41
      Related
      ENSBTAP00000027880.5, ENSBTAT00000027880.6
      Conserved Domains (3) summary
      cd10352
      Location:52 → 138
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      cd04372
      Location:275 → 468
      RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
      pfam00130
      Location:215 → 267
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    2. XM_059885477.1 → XP_059741460.1  beta-chimaerin isoform X2

    3. XM_024990557.2 → XP_024846325.1  beta-chimaerin isoform X3

      Conserved Domains (2) summary
      cd04372
      Location:84 → 277
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      pfam00130
      Location:24 → 76
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    Nucleotide Protein Strain
    Heading Accession and Version

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