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    CD80 CD80 molecule [ Bos taurus (domestic cattle) ]

    Gene ID: 407131, updated on 29-Jan-2025

    Summary

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    Official Symbol
    CD80provided by VGNC
    Official Full Name
    CD80 moleculeprovided by VGNC
    Primary source
    VGNC:VGNC:27048
    See related
    BGD:BT24275; Ensembl:ENSBTAG00000018059
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CD80 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (64296500..64325064, complement)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene protein O-glucosyltransferase 1 Neighboring gene translocase of inner mitochondrial membrane domain containing 1 Neighboring gene ADP-ribosylarginine hydrolase Neighboring gene phospholipase A1 member A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Cloning of cattle CD80. Parsons KR, et al. Immunogenetics, 1999 Mar. PMID 9914337
    2. Expression of costimulatory molecules in the bovine corpus luteum. Cannon MJ, et al. Reprod Biol Endocrinol, 2007 Jan 31. PMID 17266770, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables coreceptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell costimulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    T-lymphocyte activation antigen CD80
    Names
    CD80 antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206439.1 → NP_001193368.1  T-lymphocyte activation antigen CD80

      See identical proteins and their annotated locations for NP_001193368.1

      Status: VALIDATED

      Source sequence(s)
      DY081230, NKLS02000001, Y09950
      UniProtKB/TrEMBL
      F1MHN6, O46405
      Related
      ENSBTAP00070018613.1, ENSBTAT00070031486.1
      Conserved Domains (2) summary
      cd16083
      Location:145 → 235
      IgC_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor CD80
      cl11960
      Location:40 → 142
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      64296500..64325064 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024995021.2 → XP_024850789.1  T-lymphocyte activation antigen CD80 isoform X1

      UniProtKB/TrEMBL
      A0A3S5ZP81
      Conserved Domains (2) summary
      cd16083
      Location:145 → 235
      IgC_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor CD80
      cl11960
      Location:40 → 142
      Ig; Immunoglobulin domain

    2. XM_024994968.2 → XP_024850736.1  T-lymphocyte activation antigen CD80 isoform X1

      UniProtKB/TrEMBL
      A0A3S5ZP81
      Conserved Domains (2) summary
      cd16083
      Location:145 → 235
      IgC_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor CD80
      cl11960
      Location:40 → 142
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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