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    RDH8 retinol dehydrogenase 8 [ Bos taurus (domestic cattle) ]

    Gene ID: 281449, updated on 1-Jan-2025

    Summary

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    Official Symbol
    RDH8provided by VGNC
    Official Full Name
    retinol dehydrogenase 8provided by VGNC
    Primary source
    VGNC:VGNC:52817
    See related
    BGD:BT29463; Ensembl:ENSBTAG00000010188
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See RDH8 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (14589608..14596077)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene olfactomedin 2 Neighboring gene transfer RNA aspartic acid (anticodon GUC) Neighboring gene collagen type V alpha 3 chain Neighboring gene uncharacterized LOC132345693 Neighboring gene complement C3 Neighboring gene angiopoietin like 6 Neighboring gene shiftless antiviral inhibitor of ribosomal frameshifting

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol. Rattner A, et al. J Biol Chem, 2000 Apr 14. PMID 10753906
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in estrogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    retinol dehydrogenase 8
    Names
    photoreceptor outer segment all-trans retinol dehydrogenase
    retinol dehydrogenase 8 (all-trans)
    NP_776592.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174167.2 → NP_776592.1  retinol dehydrogenase 8

      See identical proteins and their annotated locations for NP_776592.1

      Status: PROVISIONAL

      Source sequence(s)
      AF229846
      UniProtKB/Swiss-Prot
      Q9N126
      UniProtKB/TrEMBL
      A0AAF6YUM7
      Related
      ENSBTAP00000013443.5, ENSBTAT00000013443.6
      Conserved Domains (2) summary
      cd09806
      Location:6 → 263
      type1_17beta-HSD-like_SDR_c; human estrogenic 17beta-hydroxysteroid dehydrogenase type 1 (type 1 17beta-HSD)-like, classical (c) SDRs
      pfam00106
      Location:6 → 201
      adh_short; short chain dehydrogenase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      14589608..14596077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N126.1 GenPept UniProtKB/Swiss-Prot:Q9N126

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