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    PLEKHA8 pleckstrin homology domain containing A8 [ Bos taurus (domestic cattle) ]

    Gene ID: 538919, updated on 30-Jan-2025

    Summary

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    Official Symbol
    PLEKHA8provided by VGNC
    Official Full Name
    pleckstrin homology domain containing A8provided by VGNC
    Primary source
    VGNC:VGNC:53664
    See related
    BGD:BT21492; EnsemblRapid:ENSBTAG00070029156
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    FAPP-2
    Orthologs
    human mouse all
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    Genomic context

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    See PLEKHA8 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (66219468..66328550, complement)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene zinc and ring finger 2 Neighboring gene uncharacterized LOC107132410 Neighboring gene maturin, neural progenitor differentiation regulator homolog Neighboring gene FKBP prolyl isomerase 14 Neighboring gene secernin 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables lipid transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ER to Golgi ceramide transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intermembrane lipid transfer IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family A member 8
    Names
    PH domain-containing family A member 8
    phosphatidylinositol-four-phosphate adapter protein 2
    phosphoinositol 4-phosphate adapter protein 2
    pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001197032.1 → NP_001183961.1  pleckstrin homology domain-containing family A member 8

      See identical proteins and their annotated locations for NP_001183961.1

      Status: VALIDATED

      Source sequence(s)
      NKLS02000004
      UniProtKB/Swiss-Prot
      F1MS15
      UniProtKB/TrEMBL
      A0AAF7AL81
      Related
      ENSBTAP00070040433.1, ENSBTAT00070066382.1
      Conserved Domains (3) summary
      cd01247
      Location:1 → 100
      PH_FAPP1_FAPP2; Four phosphate adaptor protein 1 and 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:1 → 93
      PH; PH domain
      pfam08718
      Location:334 → 471
      GLTP; Glycolipid transfer protein (GLTP)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      66219468..66328550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005205500.5 → XP_005205557.1  pleckstrin homology domain-containing family A member 8 isoform X3

      UniProtKB/TrEMBL
      A0AAF7AL81
      Conserved Domains (3) summary
      cd01247
      Location:1 → 100
      PH_FAPP1_FAPP2; Four phosphate adaptor protein 1 and 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:1 → 93
      PH; PH domain
      pfam08718
      Location:334 → 441
      GLTP; Glycolipid transfer protein (GLTP)

    2. XM_024990802.2 → XP_024846570.1  pleckstrin homology domain-containing family A member 8 isoform X2

      UniProtKB/TrEMBL
      A0A452DID5, A0AAF7AL81
      Conserved Domains (2) summary
      pfam08718
      Location:289 → 426
      GLTP; Glycolipid transfer protein (GLTP)
      cl17171
      Location:1 → 55
      PH-like; Pleckstrin homology-like domain

    3. XM_015469610.3 → XP_015325096.1  pleckstrin homology domain-containing family A member 8 isoform X2

      UniProtKB/TrEMBL
      A0A452DID5, A0AAF7AL81
      Conserved Domains (2) summary
      pfam08718
      Location:289 → 426
      GLTP; Glycolipid transfer protein (GLTP)
      cl17171
      Location:1 → 55
      PH-like; Pleckstrin homology-like domain

    4. XM_024990801.2 → XP_024846569.1  pleckstrin homology domain-containing family A member 8 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SNT0, A0AAA9T4X2
      Related
      ENSBTAP00070040385.1, ENSBTAT00070066327.1
      Conserved Domains (2) summary
      cd01247
      Location:1 → 100
      PH_FAPP1_FAPP2; Four phosphate adaptor protein 1 and 2 Pleckstrin homology (PH) domain
      pfam08718
      Location:334 → 429
      GLTP; Glycolipid transfer protein (GLTP)

    RNA

    1. XR_009494159.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1MS15.2 GenPept UniProtKB/Swiss-Prot:F1MS15

    Gene LinkOut

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