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    EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 347700, updated on 1-Jan-2025

    Summary

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    Official Symbol
    EIF2AK2provided by VGNC
    Official Full Name
    eukaryotic translation initiation factor 2 alpha kinase 2provided by VGNC
    Primary source
    VGNC:VGNC:28381
    See related
    BGD:BT26027; Ensembl:ENSBTAG00000008703
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    PKR; PRKR
    Orthologs
    human mouse all
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    Genomic context

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    See EIF2AK2 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (19556767..19597286, complement)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene striatin Neighboring gene HEAT repeat containing 5B Neighboring gene G-patch domain containing 11 Neighboring gene uncharacterized LOC112448863 Neighboring gene CEBPZ opposite strand Neighboring gene CCAAT enhancer binding protein zeta Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 7 Neighboring gene protein kinase D3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Modulation of PKR activity in cells infected by bovine viral diarrhea virus. Gil LH, et al. Virus Res, 2006 Mar. PMID 16194578
    2. The mRNA regulation of porcine double-stranded RNA-activated protein kinase gene. Asano A, et al. J Vet Med Sci, 2004 Dec. PMID 15644602
    3. Tumour necrosis factor alpha up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-alpha in articular chondrocytes. Gilbert SJ, et al. Biochem Soc Trans, 2002 Nov. PMID 12440939
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Infection with cp BVDV was found to induce PKR activation.
      Title: Modulation of PKR activity in cells infected by bovine viral diarrhea virus.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables double-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interferon-induced, double-stranded RNA-activated protein kinase
    Names
    protein kinase, interferon-inducible double stranded RNA dependent
    NP_835210.2
    XP_005212626.1
    XP_005212627.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178109.3 → NP_835210.2  interferon-induced, double-stranded RNA-activated protein kinase

      See identical proteins and their annotated locations for NP_835210.2

      Status: PROVISIONAL

      Source sequence(s)
      BC126646
      UniProtKB/TrEMBL
      A0JNE6, Q865A3
      Related
      ENSBTAP00000011469.4, ENSBTAT00000011469.5
      Conserved Domains (3) summary
      smart00358
      Location:101 → 166
      DSRM; Double-stranded RNA binding motif
      pfam00069
      Location:263 → 516
      Pkinase; Protein kinase domain
      cl21453
      Location:256 → 518
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      19556767..19597286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005212570.5 → XP_005212627.1  interferon-induced, double-stranded RNA-activated protein kinase isoform X2

      UniProtKB/TrEMBL
      Q865A3
      Conserved Domains (3) summary
      smart00358
      Location:101 → 166
      DSRM; Double-stranded RNA binding motif
      pfam00069
      Location:262 → 515
      Pkinase; Protein kinase domain
      cl21453
      Location:255 → 517
      PKc_like; Protein Kinases, catalytic domain

    2. XM_005212569.5 → XP_005212626.1  interferon-induced, double-stranded RNA-activated protein kinase isoform X1

      See identical proteins and their annotated locations for XP_005212626.1

      UniProtKB/TrEMBL
      A0JNE6, Q865A3
      Conserved Domains (3) summary
      smart00358
      Location:101 → 166
      DSRM; Double-stranded RNA binding motif
      pfam00069
      Location:263 → 516
      Pkinase; Protein kinase domain
      cl21453
      Location:256 → 518
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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