ITPR1 inositol 1,4,5-trisphosphate receptor type 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: ITPR1provided by VGNC
Official Full Name: inositol 1,4,5-trisphosphate receptor type 1provided by VGNC
Primary source: VGNC:VGNC:30346
See related: Ensembl:ENSBTAG00000020455
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 59

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	22	NC_037349.1 (21522784..21876694, complement)

Chromosome 22 - NC_037349.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

STIM1 and STIM2 are expressed in bovine aortic endothelial cells and they both interact with IP3R-1.
Title: STIM1 positively regulates the Ca2+ release activity of the inositol 1,4,5-trisphosphate receptor in bovine aortic endothelial cells.
we propose a model in which the partial unfolding of the suppressor domain by apo-CaM and the stepwise binding of the N lobe of CaM to the suppressor domain are important elements of calcium/CaM inhibition of IP(3)R
Title: Global dynamic conformational changes in the suppressor domain of IP3 receptor by stepwise binding of the two lobes of calmodulin.
the redox potential and Ca(2+) can regulate IP(3)R through totally different mechanisms: Ca(2+) by the indirect effect and the redox potential by direct action causing conformational changes
Title: Effects of redox potential and Ca2+ on the inositol 1,4,5-trisphosphate receptor L3-1 loop region: implications for receptor regulation.
the InsP3R/Ca2+ channel is regulated by chromogranin B
Title: A functional interaction between chromogranin B and the inositol 1,4,5-trisphosphate receptor/Ca2+ channel.
structural mapping of the amino acid sequences to several functional domains is deduced within the structure of the InsP3R1 tetramer
Title: Structure of the type 1 inositol 1,4,5-trisphosphate receptor revealed by electron cryomicroscopy.

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General gene information

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Markers

PMC343294P1 (e-PCR)
- UniSTS:273189

ha3079 (e-PCR)
- UniSTS:515639

ITPR1 (e-PCR)
- UniSTS:278585

RH124597 (e-PCR)
- UniSTS:161419

MARC_16157-16158:1018556163:1 (e-PCR)
- UniSTS:267979

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables inositol 1,4,5 trisphosphate binding	IEA Inferred from Electronic Annotation more info	PubMed
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

Names: IP3 receptor; IP3R 1; inositol 1,4,5-triphosphate receptor, type 1; insP3R1; type 1 InsP3 receptor; type 1 inositol 1,4,5-trisphosphate receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.