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    LAMC1 laminin subunit gamma 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 532572, updated on 1-Jan-2025

    Summary

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    Official Symbol
    LAMC1provided by VGNC
    Official Full Name
    laminin subunit gamma 1provided by VGNC
    Primary source
    VGNC:VGNC:50206
    See related
    BGD:BT26355; Ensembl:ENSBTAG00000011966
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See LAMC1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (64062643..64183739)

    Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene DExH-box helicase 9 Neighboring gene SHC binding and spindle associated 1 like Neighboring gene transfer RNA serine (anticodon GGA) Neighboring gene laminin subunit gamma 2 Neighboring gene uncharacterized LOC132342492 Neighboring gene nicotinamide nucleotide adenylyltransferase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Expression of novel 400-kDa laminin chains by mouse and bovine endothelial cells. Sorokin L, et al. Eur J Biochem, 1994 Jul 15. PMID 8055931
    2. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684
    3. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in substrate adhesion-dependent cell spreading IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tissue development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basement membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    laminin subunit gamma-1
    Names
    laminin, gamma 1 (formerly LAMB2)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206817.1 → NP_001193746.1  laminin subunit gamma-1 precursor

      Status: VALIDATED

      Source sequence(s)
      BC142165, BF231262, CK775026, DN285856, DT900615, DV814317, DV821469, DV877304, DV931101, DY211873, EE363840, EE383642, EH179287, NKLS02000016
      Related
      ENSBTAP00000015881.5, ENSBTAT00000015881.7
      Conserved Domains (10) summary
      cl14654
      Location:1179 → 1314
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00136
      Location:43 → 283
      LamNT; Laminin N-terminal domain (domain VI)
      smart00180
      Location:934 → 979
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:552 → 677
      LamB; Laminin B domain
      COG1842
      Location:1109 → 1332
      PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
      cd00055
      Location:882 → 932
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:444 → 491
      Laminin_EGF; Laminin EGF domain
      pfam12718
      Location:1411 → 1575
      Tropomyosin_1; Tropomyosin like
      pfam12795
      Location:1227 → 1484
      MscS_porin; Mechanosensitive ion channel porin domain
      cl02488
      Location:1034 → 1253
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      64062643..64183739
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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