DLG5 discs large MAGUK scaffold protein 5 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: DLG5provided by VGNC
Official Full Name: discs large MAGUK scaffold protein 5provided by VGNC
Primary source: VGNC:VGNC:28087
See related: BGD:BT22216; Ensembl:ENSBTAG00000013187
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 28

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	28	NC_037355.1 (33518711..33642655, complement)

Chromosome 28 - NC_037355.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037355.1 Chromosome 28 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

MARC_17381-17382:1021991004:3 (e-PCR)
- UniSTS:268292

MARC_17815-17816:1024936495:1 (e-PCR)
- UniSTS:268411

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of hippo signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: disks large homolog 5

Names: discs, large homolog 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001206088.1 → NP_001193017.1 disks large homolog 5

See identical proteins and their annotated locations for NP_001193017.1

Status: PROVISIONAL

Source sequence(s)

NKLS02000028

UniProtKB/TrEMBL

F1MSI9

Related

ENSBTAP00000017554.6, ENSBTAT00000017554.6

Conserved Domains (11) summary

cd11860
Location:1598 → 1660

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

smart00072
Location:1733 → 1909

GuKc; Guanylate kinase homologues

smart00228
Location:1346 → 1428

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:722 → 790

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1739 → 1908

Guanylate_kin; Guanylate kinase

pfam04822
Location:130 → 212

Takusan; Takusan

pfam14662
Location:335 → 560

KASH_CCD; Coiled-coil region of CCDC155 or KASH

pfam15619
Location:238 → 410

Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

pfam15743
Location:339 → 479

SPATA1_C; Spermatogenesis-associated C-terminus

pfam16610
Location:1426 → 1500

dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5

cl12013
Location:417 → 592

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037355.1 Reference ARS-UCD2.0 Primary Assembly

Range

33518711..33642655 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_010820601.4 → XP_010818903.1 disks large homolog 5 isoform X3

UniProtKB/TrEMBL

F1MSI9

Conserved Domains (11) summary

cd11860
Location:1575 → 1637

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

smart00072
Location:1710 → 1886

GuKc; Guanylate kinase homologues

smart00228
Location:1323 → 1405

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:699 → 767

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1716 → 1885

Guanylate_kin; Guanylate kinase

pfam04822
Location:107 → 189

Takusan; Takusan

pfam14662
Location:312 → 537

KASH_CCD; Coiled-coil region of CCDC155 or KASH

pfam15619
Location:215 → 387

Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

pfam15743
Location:316 → 456

SPATA1_C; Spermatogenesis-associated C-terminus

pfam16610
Location:1403 → 1477

dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5

cl12013
Location:394 → 569

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_010820600.4 → XP_010818902.1 disks large homolog 5 isoform X2

UniProtKB/TrEMBL

F1MSI9

Conserved Domains (11) summary

cd11860
Location:1577 → 1639

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

smart00072
Location:1712 → 1888

GuKc; Guanylate kinase homologues

smart00228
Location:1325 → 1407

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:699 → 767

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1718 → 1887

Guanylate_kin; Guanylate kinase

pfam04822
Location:107 → 189

Takusan; Takusan

pfam14662
Location:312 → 537

KASH_CCD; Coiled-coil region of CCDC155 or KASH

pfam15619
Location:215 → 387

Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

pfam15743
Location:316 → 456

SPATA1_C; Spermatogenesis-associated C-terminus

pfam16610
Location:1405 → 1479

dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5

cl12013
Location:394 → 569

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_024986714.2 → XP_024842482.1 disks large homolog 5 isoform X10

UniProtKB/TrEMBL

F1MSI9

Conserved Domains (9) summary

cd11860
Location:1386 → 1448

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

smart00072
Location:1521 → 1697

GuKc; Guanylate kinase homologues

smart00228
Location:1134 → 1216

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:722 → 790

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam04822
Location:129 → 213

Takusan

pfam16610
Location:1214 → 1288

dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5

cl25729
Location:189 → 407

EzrA; Septation ring formation regulator, EzrA

cl25732
Location:338 → 636

SMC_N; RecF/RecN/SMC N terminal domain

cl28033
Location:860 → 1135

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
XM_010820605.4 → XP_010818907.1 disks large homolog 5 isoform X9

UniProtKB/TrEMBL

F1MSI9

Conserved Domains (11) summary

cd11860
Location:1388 → 1450

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

smart00072
Location:1523 → 1699

GuKc; Guanylate kinase homologues

smart00228
Location:1136 → 1218

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:722 → 790

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1529 → 1698

Guanylate_kin; Guanylate kinase

pfam04822
Location:130 → 212

Takusan; Takusan

pfam14662
Location:335 → 560

KASH_CCD; Coiled-coil region of CCDC155 or KASH

pfam15619
Location:238 → 410

Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

pfam15743
Location:339 → 479

SPATA1_C; Spermatogenesis-associated C-terminus

pfam16610
Location:1216 → 1290

dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5

cl12013
Location:417 → 592

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_010820602.4 → XP_010818904.1 disks large homolog 5 isoform X4

UniProtKB/TrEMBL

F1MSI9

Conserved Domains (11) summary

cd11860
Location:1568 → 1630

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

smart00072
Location:1703 → 1879

GuKc; Guanylate kinase homologues

smart00228
Location:1316 → 1398

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:722 → 790

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1709 → 1878

Guanylate_kin; Guanylate kinase

pfam04822
Location:130 → 212

Takusan; Takusan

pfam14662
Location:335 → 560

KASH_CCD; Coiled-coil region of CCDC155 or KASH

pfam15619
Location:238 → 410

Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

pfam15743
Location:339 → 479

SPATA1_C; Spermatogenesis-associated C-terminus

pfam16610
Location:1396 → 1470

dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5

cl12013
Location:417 → 592

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_010820599.4 → XP_010818901.1 disks large homolog 5 isoform X1

UniProtKB/TrEMBL

F1MSI9

Conserved Domains (11) summary

cd11860
Location:1600 → 1662

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

smart00072
Location:1735 → 1911

GuKc; Guanylate kinase homologues

smart00228
Location:1348 → 1430

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:722 → 790

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1741 → 1910

Guanylate_kin; Guanylate kinase

pfam04822
Location:130 → 212

Takusan; Takusan

pfam14662
Location:335 → 560

KASH_CCD; Coiled-coil region of CCDC155 or KASH

pfam15619
Location:238 → 410

Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

pfam15743
Location:339 → 479

SPATA1_C; Spermatogenesis-associated C-terminus

pfam16610
Location:1428 → 1502

dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5

cl12013
Location:417 → 592

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_024986712.2 → XP_024842480.1 disks large homolog 5 isoform X5

UniProtKB/TrEMBL

A0A3Q1NMF2

Related

ENSBTAP00000073770.2, ENSBTAT00000070535.2

Conserved Domains (9) summary

cd11860
Location:1554 → 1616

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

smart00072
Location:1689 → 1865

GuKc; Guanylate kinase homologues

smart00228
Location:1302 → 1384

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:676 → 744

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam04822
Location:83 → 167

Takusan

pfam16610
Location:1382 → 1456

dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5

cl25729
Location:143 → 361

EzrA; Septation ring formation regulator, EzrA

cl25732
Location:292 → 590

SMC_N; RecF/RecN/SMC N terminal domain

cl26464
Location:828 → 1273

Atrophin-1; Atrophin-1 family
XM_015461004.3 → XP_015316490.1 disks large homolog 5 isoform X6

UniProtKB/TrEMBL

A0A3Q1NMF2

Conserved Domains (11) summary

cd11860
Location:1490 → 1552

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

smart00072
Location:1625 → 1801

GuKc; Guanylate kinase homologues

smart00228
Location:1238 → 1320

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:612 → 680

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1631 → 1800

Guanylate_kin; Guanylate kinase

pfam04822
Location:20 → 102

Takusan; Takusan

pfam14662
Location:225 → 450

KASH_CCD; Coiled-coil region of CCDC155 or KASH

pfam15619
Location:128 → 300

Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

pfam15743
Location:229 → 369

SPATA1_C; Spermatogenesis-associated C-terminus

pfam16610
Location:1318 → 1392

dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5

cl12013
Location:307 → 482

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_024986713.2 → XP_024842481.1 disks large homolog 5 isoform X7

UniProtKB/TrEMBL

A0A3Q1NMF2

Conserved Domains (9) summary

cd11860
Location:1488 → 1550

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

smart00072
Location:1623 → 1799

GuKc; Guanylate kinase homologues

smart00228
Location:1236 → 1318

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:612 → 680

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam04822
Location:19 → 103

Takusan

pfam16610
Location:1316 → 1390

dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5

cl25729
Location:79 → 297

EzrA; Septation ring formation regulator, EzrA

cl25732
Location:228 → 526

SMC_N; RecF/RecN/SMC N terminal domain

cl26464
Location:764 → 1207

Atrophin-1; Atrophin-1 family
XM_059882561.1 → XP_059738544.1 disks large homolog 5 isoform X8

UniProtKB/TrEMBL

A0A3Q1NMF2