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    BUB1 BUB1 mitotic checkpoint serine/threonine kinase [ Bos taurus (domestic cattle) ]

    Gene ID: 514777, updated on 1-Jan-2025

    Summary

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    Official Symbol
    BUB1provided by VGNC
    Official Full Name
    BUB1 mitotic checkpoint serine/threonine kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:26604
    See related
    BGD:BT30260; Ensembl:ENSBTAG00000021181
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See BUB1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (1585410..1618579)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132346534 Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene BCL2 like 11 Neighboring gene acyl-CoA oxidase like Neighboring gene U6 spliceosomal RNA Neighboring gene two pore channel 3 Neighboring gene mitoregulin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC148432

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in meiotic sister chromatid cohesion, centromeric IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitotic checkpoint serine/threonine-protein kinase BUB1
    Names
    BUB1 budding uninhibited by benzimidazoles 1 homolog
    budding uninhibited by benzimidazoles 1 homolog
    NP_001095481.1
    XP_005212373.1
    XP_059747196.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102011.2 → NP_001095481.1  mitotic checkpoint serine/threonine-protein kinase BUB1

      See identical proteins and their annotated locations for NP_001095481.1

      Status: PROVISIONAL

      Source sequence(s)
      BC148104
      UniProtKB/TrEMBL
      A0AAA9TND6, A6QLW0
      Related
      ENSBTAP00000100034.1, ENSBTAT00000092233.1
      Conserved Domains (2) summary
      pfam08311
      Location:6 → 125
      Mad3_BUB1_I; Mad3/BUB1 homology region 1
      cl21453
      Location:778 → 1066
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      1585410..1618579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005212316.4 → XP_005212373.1  mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1

      UniProtKB/TrEMBL
      A0AAA9TND6, F6Q5Z6
      Related
      ENSBTAP00000028226.5, ENSBTAT00000028226.6
      Conserved Domains (2) summary
      pfam08311
      Location:6 → 125
      Mad3_BUB1_I; Mad3/BUB1 homology region 1
      cl21453
      Location:781 → 1069
      PKc_like; Protein Kinases, catalytic domain

    2. XM_059891213.1 → XP_059747196.1  mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X2

      UniProtKB/TrEMBL
      A0AAA9TND6
    Nucleotide Protein Strain
    Heading Accession and Version

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