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    ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 282144, updated on 29-Jan-2025

    Summary

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    Official Symbol
    ATP1A1provided by VGNC
    Official Full Name
    ATPase Na+/K+ transporting subunit alpha 1provided by VGNC
    Primary source
    VGNC:VGNC:26282
    See related
    BGD:BT11164; Ensembl:ENSBTAG00000001246
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ATP1A1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (26886570..26918899, complement)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily member 3 Neighboring gene CD58 molecule Neighboring gene uncharacterized LOC132344852 Neighboring gene uncharacterized LOC104971541

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Deficiency in the α1 subunit of Na+/K+-ATPase enhances the anti-proliferative effect of high osmolality in nucleus pulposus intervertebral disc cells. Mavrogonatou E, et al. J Cell Physiol, 2015 Dec. PMID 25967398
    2. Na/K-ATPase regulates bovine sperm capacitation through raft- and non-raft-mediated signaling mechanisms. Rajamanickam GD, et al. Mol Reprod Dev, 2017 Nov. PMID 28833817
    3. Polymorphisms of the ATP1A1 gene associated with mastitis in dairy cattle. Liu YX, et al. Genet Mol Res, 2012 Mar 16. PMID 22535401
    4. Association of ATP1A1 gene polymorphism with heat tolerance traits in dairy cattle. Liu YX, et al. Genet Mol Res, 2010 May 11. PMID 20467982
    5. Phospholemman, a single-span membrane protein, is an accessory protein of Na,K-ATPase in cerebellum and choroid plexus. Feschenko MS, et al. J Neurosci, 2003 Mar 15. PMID 12657675, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Suggest ATP1A1 has a central role in the osmoregulatory response of nucleus pulposus cells.
      Title: Deficiency in the α1 subunit of Na+/K+-ATPase enhances the anti-proliferative effect of high osmolality in nucleus pulposus intervertebral disc cells.
    2. The ATP1A1 gene polymorphism has potential as a marker for mastitis resistance in dairy cattle.
      Title: Polymorphisms of the ATP1A1 gene associated with mastitis in dairy cattle.
    3. The polymorphisms within the coding region of bovine ATP1A1 gene, were analyzed.
      Title: A novel SNP of the ATP1A1 gene is associated with heat tolerance traits in dairy cows.
    4. ATP1A1 gene polymorphism has a role in heat tolerance traits in dairy cattle
      Title: Association of ATP1A1 gene polymorphism with heat tolerance traits in dairy cattle.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables P-type sodium:potassium-exchanging transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular potassium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular sodium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in potassium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sodium ion export across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of sodium:potassium-exchanging ATPase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sodium/potassium-transporting ATPase subunit alpha-1
    Names
    ATPase, Na+/K+ transporting, alpha 1 polypeptide
    Na(+)/K(+) ATPase alpha-1 subunit
    sodium pump subunit alpha-1
    NP_001070266.1
    XP_059737690.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076798.1 → NP_001070266.1  sodium/potassium-transporting ATPase subunit alpha-1

      See identical proteins and their annotated locations for NP_001070266.1

      Status: PROVISIONAL

      Source sequence(s)
      BC123864
      UniProtKB/Swiss-Prot
      Q08DA1
      UniProtKB/TrEMBL
      F1MI32
      Related
      ENSBTAP00070049933.1, ENSBTAT00070082446.1
      Conserved Domains (6) summary
      smart00831
      Location:38 → 112
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      COG4087
      Location:604 → 750
      COG4087; Soluble P-type ATPase [General function prediction only]
      TIGR01106
      Location:25 → 1021
      ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit
      pfam00122
      Location:132 → 363
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:797 → 1006
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam13246
      Location:425 → 519
      Cation_ATPase; Cation transport ATPase (P-type)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      26886570..26918899 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059881707.1 → XP_059737690.1  sodium/potassium-transporting ATPase subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A0AAA9RXW7, F1MI32
      Related
      ENSBTAP00070049928.1, ENSBTAT00070082441.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08DA1.1 GenPept UniProtKB/Swiss-Prot:Q08DA1

    Gene LinkOut

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