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    PHLDB2 pleckstrin homology like domain family B member 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 509784, updated on 27-Dec-2024

    Summary

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    Official Symbol
    PHLDB2provided by VGNC
    Official Full Name
    pleckstrin homology like domain family B member 2provided by VGNC
    Primary source
    VGNC:VGNC:32838
    See related
    BGD:BT20789; Ensembl:ENSBTAG00000001209
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PHLDB2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (56486679..56728489)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104970843 Neighboring gene phosphatidylinositol specific phospholipase C X domain containing 2 Neighboring gene uncharacterized LOC112447299 Neighboring gene uncharacterized LOC112447298 Neighboring gene abhydrolase domain containing 10, depalmitoylase Neighboring gene transgelin 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in regulation of microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basal cortex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pleckstrin homology-like domain family B member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206308.1 → NP_001193237.1  pleckstrin homology-like domain family B member 2

      See identical proteins and their annotated locations for NP_001193237.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000001
      UniProtKB/TrEMBL
      A0A3Q1M8W3
      Related
      ENSBTAP00000066908.2, ENSBTAT00000074047.2
      Conserved Domains (4) summary
      cd14673
      Location:1143 → 1247
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1146 → 1242
      PH; PH domain
      cl02488
      Location:601 → 790
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl19107
      Location:1037 → 1107
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      56486679..56728489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015471035.3 → XP_015326521.1  pleckstrin homology-like domain family B member 2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M8W3
      Conserved Domains (4) summary
      cd14673
      Location:1256 → 1360
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1259 → 1355
      PH; PH domain
      cl02488
      Location:628 → 817
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl19107
      Location:1150 → 1220
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    2. XM_005201281.5 → XP_005201338.1  pleckstrin homology-like domain family B member 2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1M8W3
      Conserved Domains (4) summary
      cd14673
      Location:1232 → 1336
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1235 → 1331
      PH; PH domain
      cl02488
      Location:628 → 817
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl19107
      Location:1126 → 1196
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    3. XM_015471043.3 → XP_015326529.1  pleckstrin homology-like domain family B member 2 isoform X6

      UniProtKB/TrEMBL
      A0A3Q1M8W3
      Conserved Domains (4) summary
      cd14673
      Location:1194 → 1298
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1197 → 1293
      PH; PH domain
      cl02488
      Location:628 → 817
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl19107
      Location:1088 → 1158
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    4. XM_015471046.3 → XP_015326532.1  pleckstrin homology-like domain family B member 2 isoform X7

      UniProtKB/TrEMBL
      A0A3Q1M8W3
      Conserved Domains (4) summary
      cd14673
      Location:1170 → 1274
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1173 → 1269
      PH; PH domain
      cl02488
      Location:628 → 817
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl19107
      Location:1064 → 1134
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    5. XM_015471050.3 → XP_015326536.1  pleckstrin homology-like domain family B member 2 isoform X8

      UniProtKB/TrEMBL
      A0A3Q1M8W3
      Conserved Domains (4) summary
      cd14673
      Location:1146 → 1250
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1149 → 1245
      PH; PH domain
      cl02488
      Location:628 → 817
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl19107
      Location:1040 → 1110
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    6. XM_059876860.1 → XP_059732843.1  pleckstrin homology-like domain family B member 2 isoform X10

      UniProtKB/TrEMBL
      A0A3Q1M8W3

    7. XM_015471053.3 → XP_015326539.1  pleckstrin homology-like domain family B member 2 isoform X11

      UniProtKB/TrEMBL
      A0A3Q1NFK8
      Conserved Domains (4) summary
      cd14673
      Location:1099 → 1203
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1102 → 1198
      PH; PH domain
      cl02488
      Location:628 → 817
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl19107
      Location:993 → 1063
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    8. XM_024977109.2 → XP_024832877.1  pleckstrin homology-like domain family B member 2 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1M8W3
      Conserved Domains (3) summary
      cd14673
      Location:1226 → 1330
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      cl25732
      Location:612 → 825
      SMC_N; RecF/RecN/SMC N terminal domain
      cl25742
      Location:1118 → 1190
      ERM; Ezrin/radixin/moesin family

    9. XM_015471042.3 → XP_015326528.1  pleckstrin homology-like domain family B member 2 isoform X5

      UniProtKB/TrEMBL
      E1BBH1
      Conserved Domains (4) summary
      cd14673
      Location:1213 → 1317
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1216 → 1312
      PH; PH domain
      cl09111
      Location:627 → 767
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cl19107
      Location:1107 → 1177
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    10. XM_015471052.3 → XP_015326538.1  pleckstrin homology-like domain family B member 2 isoform X9

      UniProtKB/TrEMBL
      E1BBH1
      Conserved Domains (4) summary
      cd14673
      Location:1127 → 1231
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1130 → 1226
      PH; PH domain
      cl09111
      Location:627 → 767
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cl19107
      Location:1021 → 1091
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    11. XM_059876894.1 → XP_059732877.1  pleckstrin homology-like domain family B member 2 isoform X12

      UniProtKB/TrEMBL
      A0A3Q1NFK8

    12. XM_059876682.1 → XP_059732665.1  pleckstrin homology-like domain family B member 2 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1M8W3

    13. XM_015471038.3 → XP_015326524.1  pleckstrin homology-like domain family B member 2 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1M8W3
      Conserved Domains (4) summary
      cd14673
      Location:1229 → 1333
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1232 → 1328
      PH; PH domain
      cl02488
      Location:601 → 790
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl19107
      Location:1123 → 1193
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    Nucleotide Protein Strain
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