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    TFRC transferrin receptor [ Bos taurus (domestic cattle) ]

    Gene ID: 504698, updated on 27-Dec-2024

    Summary

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    Official Symbol
    TFRCprovided by VGNC
    Official Full Name
    transferrin receptorprovided by VGNC
    Primary source
    VGNC:VGNC:35797
    See related
    BGD:BT20728; Ensembl:ENSBTAG00000032719
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See TFRC in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (70650067..70680786, complement)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene tyrosine kinase non receptor 2 Neighboring gene uncharacterized LOC101906292 Neighboring gene zinc finger DHHC-type palmitoyltransferase 19 Neighboring gene solute carrier family 51 subunit alpha Neighboring gene phosphate cytidylyltransferase 1A, choline

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables transferrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transferrin transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transferrin receptor protein 1
    Names
    transferrin receptor (p90, CD71)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206577.1 → NP_001193506.1  transferrin receptor protein 1

      Status: VALIDATED

      Source sequence(s)
      DV818910, DV891962, NKLS02000001
      UniProtKB/TrEMBL
      E1BIG6
      Related
      ENSBTAP00000043726.5, ENSBTAT00000046421.5
      Conserved Domains (3) summary
      cd02128
      Location:210 → 386
      PA_TfR; PA_TfR: Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 ...
      pfam04253
      Location:651 → 755
      TFR_dimer; Transferrin receptor-like dimerisation domain
      cl14876
      Location:376 → 619
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      70650067..70680786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024996557.1 → XP_024852325.1  transferrin receptor protein 1 isoform X1

      UniProtKB/TrEMBL
      E1BIG6
      Conserved Domains (3) summary
      cd02128
      Location:210 → 386
      PA_TfR; PA_TfR: Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 ...
      pfam04253
      Location:651 → 755
      TFR_dimer; Transferrin receptor-like dimerisation domain
      cl14876
      Location:376 → 619
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    2. XM_024996516.2 → XP_024852284.1  transferrin receptor protein 1 isoform X1

      UniProtKB/TrEMBL
      E1BIG6
      Conserved Domains (3) summary
      cd02128
      Location:210 → 386
      PA_TfR; PA_TfR: Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 ...
      pfam04253
      Location:651 → 755
      TFR_dimer; Transferrin receptor-like dimerisation domain
      cl14876
      Location:376 → 619
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    3. XM_024996657.2 → XP_024852425.1  transferrin receptor protein 1 isoform X1

      UniProtKB/TrEMBL
      E1BIG6
      Conserved Domains (3) summary
      cd02128
      Location:210 → 386
      PA_TfR; PA_TfR: Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 ...
      pfam04253
      Location:651 → 755
      TFR_dimer; Transferrin receptor-like dimerisation domain
      cl14876
      Location:376 → 619
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
    Nucleotide Protein Strain
    Heading Accession and Version

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