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    OPTN optineurin [ Bos taurus (domestic cattle) ]

    Gene ID: 534150, updated on 27-Dec-2024

    Summary

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    Official Symbol
    OPTNprovided by VGNC
    Official Full Name
    optineurinprovided by VGNC
    Primary source
    VGNC:VGNC:32442
    See related
    BGD:BT14721; Ensembl:ENSBTAG00000016401
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See OPTN in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (27800797..27839665)

    Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene U6atac minor spliceosomal RNA Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene minichromosome maintenance 10 replication initiation factor Neighboring gene upper zone of growth plate and cartilage matrix associated

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC128158

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables K63-linked polyubiquitin modification-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi ribbon formation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein localization to Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    optineurin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034602.1 → NP_001029774.1  optineurin

      See identical proteins and their annotated locations for NP_001029774.1

      Status: PROVISIONAL

      Source sequence(s)
      BC102937
      UniProtKB/TrEMBL
      Q3ZC32
      Related
      ENSBTAP00000021808.3, ENSBTAT00000021808.5
      Conserved Domains (3) summary
      cd09803
      Location:415 → 501
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      pfam11577
      Location:37 → 104
      NEMO; NF-kappa-B essential modulator NEMO
      cl25732
      Location:39 → 416
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      27800797..27839665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059892685.1 → XP_059748668.1  optineurin isoform X1

      UniProtKB/TrEMBL
      Q3ZC32

    2. XM_005214208.5 → XP_005214265.1  optineurin isoform X1

      See identical proteins and their annotated locations for XP_005214265.1

      UniProtKB/TrEMBL
      Q3ZC32
      Conserved Domains (3) summary
      cd09803
      Location:415 → 501
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      pfam11577
      Location:37 → 104
      NEMO; NF-kappa-B essential modulator NEMO
      cl25732
      Location:39 → 416
      SMC_N; RecF/RecN/SMC N terminal domain

    3. XM_005214212.5 → XP_005214269.1  optineurin isoform X2

      Conserved Domains (2) summary
      pfam11577
      Location:37 → 104
      NEMO; NF-kappa-B essential modulator NEMO
      pfam16516
      Location:399 → 498
      CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator

    4. XM_025000708.2 → XP_024856476.1  optineurin isoform X1

      UniProtKB/TrEMBL
      Q3ZC32
      Conserved Domains (3) summary
      cd09803
      Location:415 → 501
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      pfam11577
      Location:37 → 104
      NEMO; NF-kappa-B essential modulator NEMO
      cl25732
      Location:39 → 416
      SMC_N; RecF/RecN/SMC N terminal domain

    5. XM_005214211.5 → XP_005214268.1  optineurin isoform X1

      See identical proteins and their annotated locations for XP_005214268.1

      UniProtKB/TrEMBL
      Q3ZC32
      Conserved Domains (3) summary
      cd09803
      Location:415 → 501
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      pfam11577
      Location:37 → 104
      NEMO; NF-kappa-B essential modulator NEMO
      cl25732
      Location:39 → 416
      SMC_N; RecF/RecN/SMC N terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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