U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    KCNH1 potassium voltage-gated channel subfamily H member 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 281881, updated on 1-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    KCNH1provided by VGNC
    Official Full Name
    potassium voltage-gated channel subfamily H member 1provided by VGNC
    Primary source
    VGNC:VGNC:50204
    See related
    Ensembl:ENSBTAG00000008710
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    EAG; bEAG; bEAG1
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See KCNH1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (72205829..72647121)

    Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100336777 Neighboring gene uncharacterized LOC132342425 Neighboring gene REST corepressor 3 Neighboring gene uncharacterized LOC132342504 Neighboring gene transfer RNA arginine (anticodon GCG) Neighboring gene U6 spliceosomal RNA Neighboring gene hedgehog acyltransferase Neighboring gene uncharacterized LOC112441911

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Characterization of ether-à-go-go channels present in photoreceptors reveals similarity to IKx, a K+ current in rod inner segments. Frings S, et al. J Gen Physiol, 1998 Apr. PMID 9524140, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables delayed rectifier potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    voltage-gated delayed rectifier potassium channel KCNH1
    Names
    ether-a-go-go potassium channel 1
    potassium channel, voltage gated eag related subfamily H, member 1
    potassium voltage-gated channel, subfamily H (eag-related), member 1
    voltage-gated potassium channel subunit Kv10.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174372.2 → NP_776797.1  voltage-gated delayed rectifier potassium channel KCNH1

      See identical proteins and their annotated locations for NP_776797.1

      Status: PROVISIONAL

      Source sequence(s)
      Y13431
      UniProtKB/Swiss-Prot
      O18965, O18966
      Related
      ENSBTAP00000011477.6, ENSBTAT00000011477.6
      Conserved Domains (6) summary
      COG0664
      Location:575 → 720
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:581 → 691
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:39 → 133
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:235 → 510
      Ion_trans; Ion transport protein
      pfam07885
      Location:450 → 504
      Ion_trans_2; Ion channel
      pfam13426
      Location:39 → 135
      PAS_9; PAS domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      72205829..72647121
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024976030.2 → XP_024831798.1  voltage-gated delayed rectifier potassium channel KCNH1 isoform X1

      Conserved Domains (4) summary
      pfam13426
      Location:41 → 135
      PAS_9; PAS domain
      cl26073
      Location:220 → 620
      Ank_2; Ankyrin repeats (3 copies)
      cl27543
      Location:841 → 927
      PRK13004; peptidase; Reviewed
      cl28240
      Location:581 → 685
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18965.2 GenPept UniProtKB/Swiss-Prot:O18965

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.