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    ACVR1 activin A receptor type 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 338068, updated on 1-Jan-2025

    Summary

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    Official Symbol
    ACVR1provided by VGNC
    Official Full Name
    activin A receptor type 1provided by VGNC
    Primary source
    VGNC:VGNC:25592
    See related
    BGD:BT11316; Ensembl:ENSBTAG00000011909
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    ACVR1A; ActR-IA
    Orthologs
    human mouse all
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    Genomic context

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    See ACVR1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (38466792..38597896)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC101907729 Neighboring gene activin A receptor type 1C Neighboring gene cytohesin 1 interacting protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Expression of bone morphogenetic protein2 (BMP2), BMP4 and BMP receptors in the bovine ovary but absence of effects of BMP2 and BMP4 during IVM on bovine oocyte nuclear maturation and subsequent embryo development. Fatehi AN, et al. Theriogenology, 2005 Feb. PMID 15629804
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane receptor protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of BMP receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    activin receptor type-1
    Names
    ACTR-I
    SKR1
    activin A receptor, type I
    activin receptor type I
    serine/threonine-protein kinase receptor R1
    NP_788836.2
    XP_024855045.1
    XP_024855049.1
    XP_059747901.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176663.3 → NP_788836.2  activin receptor type-1 precursor

      See identical proteins and their annotated locations for NP_788836.2

      Status: PROVISIONAL

      Source sequence(s)
      BC133311
      UniProtKB/Swiss-Prot
      Q28041
      UniProtKB/TrEMBL
      A2VDM5
      Related
      ENSBTAP00000077939.1, ENSBTAT00000126016.1
      Conserved Domains (3) summary
      cd14142
      Location:202 → 499
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:33 → 103
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:179 → 206
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      38466792..38597896
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024999277.2 → XP_024855045.1  activin receptor type-1 isoform X1

      UniProtKB/Swiss-Prot
      Q28041
      UniProtKB/TrEMBL
      A2VDM5
      Related
      ENSBTAP00000081608.1, ENSBTAT00000124663.1
      Conserved Domains (3) summary
      cd14142
      Location:202 → 499
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:33 → 103
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:179 → 206
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    2. XM_024999281.2 → XP_024855049.1  activin receptor type-1 isoform X1

      UniProtKB/Swiss-Prot
      Q28041
      UniProtKB/TrEMBL
      A2VDM5
      Related
      ENSBTAP00000093079.1, ENSBTAT00000109508.1
      Conserved Domains (3) summary
      cd14142
      Location:202 → 499
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:33 → 103
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:179 → 206
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    3. XM_059891918.1 → XP_059747901.1  activin receptor type-1 isoform X2

      UniProtKB/Swiss-Prot
      Q28041
      UniProtKB/TrEMBL
      A0AAA9SLD5
      Related
      ENSBTAP00000083459.1, ENSBTAT00000126859.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28041.1 GenPept UniProtKB/Swiss-Prot:Q28041

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials