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    HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 533336, updated on 1-Jan-2025

    Summary

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    Official Symbol
    HERC4provided by VGNC
    Official Full Name
    HECT and RLD domain containing E3 ubiquitin protein ligase 4provided by VGNC
    Primary source
    VGNC:VGNC:55988
    See related
    Ensembl:ENSBTAG00000014029
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See HERC4 in Genome Data Viewer
    Location:
    chromosome: 28
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 28 NC_037355.1 (24436931..24564423, complement)

    Chromosome 28 - NC_037355.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C12 Neighboring gene small ribosomal subunit protein eS24-like Neighboring gene sirtuin 1 Neighboring gene myopalladin Neighboring gene atonal bHLH transcription factor 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037355.1 Chromosome 28 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC142977

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase HERC4
    Names
    hect domain and RLD 4
    NP_001070362.2
    XP_005226469.1
    XP_010818893.1
    XP_010818895.1
    XP_059738527.1
    XP_059738528.1
    XP_059738529.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076894.3 → NP_001070362.2  probable E3 ubiquitin-protein ligase HERC4

      See identical proteins and their annotated locations for NP_001070362.2

      Status: VALIDATED

      Source sequence(s)
      NKLS02000028
      UniProtKB/TrEMBL
      A0A3Q1LS42, E1BAV2
      Related
      ENSBTAP00000018639.5, ENSBTAT00000018639.6
      Conserved Domains (3) summary
      smart00119
      Location:735 → 1054
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:709 → 1055
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00415
      Location:208 → 257
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037355.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      24436931..24564423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005226412.4 → XP_005226469.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

      See identical proteins and their annotated locations for XP_005226469.1

      UniProtKB/TrEMBL
      A0A3Q1LYN7
      Related
      ENSBTAP00000060755.2, ENSBTAT00000074679.2
      Conserved Domains (3) summary
      smart00119
      Location:727 → 1046
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:701 → 1047
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00415
      Location:208 → 257
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    2. XM_010820591.4 → XP_010818893.1  probable E3 ubiquitin-protein ligase HERC4 isoform X2

      See identical proteins and their annotated locations for XP_010818893.1

      UniProtKB/TrEMBL
      A0AAA9TY52
      Related
      ENSBTAP00000102128.1, ENSBTAT00000098927.1
      Conserved Domains (2) summary
      cd00078
      Location:639 → 985
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cl27697
      Location:12 → 268
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    3. XM_059882544.1 → XP_059738527.1  probable E3 ubiquitin-protein ligase HERC4 isoform X3

      UniProtKB/TrEMBL
      A0AAA9TY52

    4. XM_010820593.3 → XP_010818895.1  probable E3 ubiquitin-protein ligase HERC4 isoform X4

      UniProtKB/TrEMBL
      Q08DB6
      Conserved Domains (2) summary
      pfam00415
      Location:208 → 257
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      cl00077
      Location:709 → 866
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    5. XM_059882545.1 → XP_059738528.1  probable E3 ubiquitin-protein ligase HERC4 isoform X5

    6. XM_059882546.1 → XP_059738529.1  probable E3 ubiquitin-protein ligase HERC4 isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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