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    IGFBP2 insulin like growth factor binding protein 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 282260, updated on 27-Dec-2024

    Summary

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    Official Symbol
    IGFBP2provided by VGNC
    Official Full Name
    insulin like growth factor binding protein 2provided by VGNC
    Primary source
    VGNC:VGNC:30084
    See related
    BGD:BT10909; Ensembl:ENSBTAG00000005596
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See IGFBP2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (104619962..104648632)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1 Neighboring gene ribosomal protein L37a Neighboring gene insulin like growth factor binding protein 5 Neighboring gene transfer RNA serine (anticodon GGA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Associations between bovine IGFBP2 polymorphisms with fertility, milk production, and metabolic status in UK dairy cows. Clempson AM, et al. Anim Biotechnol, 2012 Apr. PMID 22537059
    2. Alanine screening mutagenesis establishes tyrosine 60 of bovine insulin-like growth factor binding protein-2 as a determinant of insulin-like growth factor binding. Hobba GD, et al. J Biol Chem, 1998 Jul 31. PMID 9677398
    3. The bovine insulin-like growth factor (IGF) binding protein purified from conditioned medium requires the N-terminal tripeptide in IGF-1 for binding. Szabo L, et al. Biochem Biophys Res Commun, 1988 Feb 29. PMID 2450535
    4. Characterization and cloning of a bovine insulin-like growth factor-binding protein. Upton FZ, et al. J Mol Endocrinol, 1990 Aug. PMID 1697752
    5. Cloning and sequence determination of bovine insulin-like growth factor binding protein-2 (IGFBP-2): comparison of its structural and functional properties with IGFBP-1. Bourner MJ, et al. J Cell Biochem, 1992 Feb. PMID 1377702

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Five novel SNPs were identified in IGFBP2, two of which had significant associations with fertility (age at conception in heifers and commencement of luteal activity) and 305-day milk yield in lactation 1.
      Title: Associations between bovine IGFBP2 polymorphisms with fertility, milk production, and metabolic status in UK dairy cows.
    2. The present study suggests that the insulin like growth factor (IGF) system or imbalances between IGF and IGF binding proteins may be involved in cystic ovary disease of cattle.
      Title: Influence of insulin-like growth factor-binding proteins-2 and -3 in the pathogenesis of cystic ovarian disease in cattle.
    3. in preovulatory follicles, PAPP-A is responsible for IGF-dependent IGFBP-2 degradation
      Title: Pregnancy-associated plasma protein-A is involved in insulin-like growth factor binding protein-2 (IGFBP-2) proteolytic degradation in bovine and porcine preovulatory follicles: identification of cleavage site and characterization of IGFBP-2 degradation.
    4. spatial and temporal patterns of expression of IGFBP-2 and -3 were markedly altered in the placentomes of nuclear transfer pregnancies
      Title: Insulin-like growth factor-I and binding proteins 1, 2, and 3 in bovine nuclear transfer pregnancies.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables insulin-like growth factor I binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables insulin-like growth factor II binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    insulin-like growth factor-binding protein 2
    Names
    IBP-2
    IGF-binding protein 2
    IGFBP-2
    insulin-like growth factor binding protein 2, 36kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174555.1 → NP_776980.1  insulin-like growth factor-binding protein 2 precursor

      See identical proteins and their annotated locations for NP_776980.1

      Status: PROVISIONAL

      Source sequence(s)
      AF074854
      UniProtKB/Swiss-Prot
      O97599, P13384
      UniProtKB/TrEMBL
      A0AAF6YNV3
      Related
      ENSBTAP00000007349.7, ENSBTAT00000007349.7
      Conserved Domains (2) summary
      smart00121
      Location:37 → 124
      IB; Insulin growth factor-binding protein homologues
      pfam00086
      Location:219 → 298
      Thyroglobulin_1; Thyroglobulin type-1 repeat

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      104619962..104648632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13384.2 GenPept UniProtKB/Swiss-Prot:P13384

    Gene LinkOut

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