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    LDHA lactate dehydrogenase A [ Bos taurus (domestic cattle) ]

    Gene ID: 281274, updated on 1-Jan-2025

    Summary

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    Gene symbol
    LDHA
    Gene description
    lactate dehydrogenase A
    See related
    BGD:BT10370; Ensembl:ENSBTAG00000008683
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
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    Genomic context

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    See LDHA in Genome Data Viewer
    Location:
    chromosome: 29
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (26290889..26302946, complement)

    Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene tumor susceptibility 101 Neighboring gene WW domain-binding protein 2-like Neighboring gene lactate dehydrogenase C Neighboring gene uncharacterized LOC132344183 Neighboring gene uncharacterized LOC104976244 Neighboring gene uncharacterized LOC132344184 Neighboring gene general transcription factor IIH subunit 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Primary structure of bovine lactate dehydrogenase-A isozyme and its synthesis in Escherichia coli. Ishiguro N, et al. Gene, 1990 Jul 16. PMID 2210387
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables L-lactate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lactate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in pyruvate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    L-lactate dehydrogenase A chain
    Names
    LDH muscle subunit
    LDH-A
    LDH-M
    NP_776524.1
    XP_005226796.1
    XP_010819169.1
    XP_059738736.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174099.2 → NP_776524.1  L-lactate dehydrogenase A chain

      See identical proteins and their annotated locations for NP_776524.1

      Status: PROVISIONAL

      Source sequence(s)
      D90143
      UniProtKB/Swiss-Prot
      A6H7E0, P19858
      UniProtKB/TrEMBL
      A0A3Q1LY19
      Conserved Domains (1) summary
      cd05293
      Location:19 → 329
      LDH_1; A subgroup of L-lactate dehydrogenases

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      26290889..26302946 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010820867.3 → XP_010819169.1  L-lactate dehydrogenase A chain isoform X1

      UniProtKB/TrEMBL
      A0AAA9T2Y5
      Related
      ENSBTAP00000093153.1, ENSBTAT00000115709.1
      Conserved Domains (2) summary
      cd05293
      Location:76 → 386
      LDH_1; A subgroup of L-lactate dehydrogenases
      TIGR01771
      Location:82 → 381
      L-LDH-NAD; L-lactate dehydrogenase

    2. XM_005226739.4 → XP_005226796.1  L-lactate dehydrogenase A chain isoform X3

      See identical proteins and their annotated locations for XP_005226796.1

      UniProtKB/Swiss-Prot
      A6H7E0, P19858
      UniProtKB/TrEMBL
      A0A3Q1LY19
      Related
      ENSBTAP00000047729.3, ENSBTAT00000056276.4
      Conserved Domains (1) summary
      cd05293
      Location:19 → 329
      LDH_1; A subgroup of L-lactate dehydrogenases

    3. XM_059882753.1 → XP_059738736.1  L-lactate dehydrogenase A chain isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LY19, A0AAF6YSZ5
      Related
      ENSBTAP00000011447.4, ENSBTAT00000011447.5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19858.2 GenPept UniProtKB/Swiss-Prot:P19858

    Gene LinkOut

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