F9 coagulation factor IX [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: F9provided by VGNC
Official Full Name: coagulation factor IXprovided by VGNC
Primary source: VGNC:VGNC:28691
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
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Genomic context

Location:: chromosome: Un

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	Unplaced Scaffold	NW_020192292.1 (5524358..5558281, complement)

NW_020192292.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NW_020192292 Unplaced Scaffold Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

structural features within residues of the 39-loop contribute to the resistance of FIXa to inhibition by plasma inhibitors ZPI and TFPI.
Title: Residues of the 39-loop restrict the plasma inhibitor specificity of factor IXa.
Mg2+ ions are required to maintain native conformation and in vivo function of factor IX gamma-carboxyglutamic acid domain
Title: Crystal structure of Mg2+- and Ca2+-bound Gla domain of factor IX complexed with binding protein.

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General gene information

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Markers

F9 (e-PCR), detects polymorphism
- UniSTS:266922

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: coagulation factor IX

Names: christmas factor; coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B); plasma thromboplastic component

NP_001096690.1

EC 3.4.21.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001103220.1 → NP_001096690.1 coagulation factor IX

See identical proteins and their annotated locations for NP_001096690.1

Status: PROVISIONAL

Source sequence(s)

BC149563

UniProtKB/TrEMBL

A6QPZ2

Conserved Domains (2) summary

smart00020
Location:90 → 318

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:91 → 321

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...