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    STK10 serine/threonine kinase 10 [ Bos taurus (domestic cattle) ]

    Gene ID: 526376, updated on 27-Dec-2024

    Summary

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    Official Symbol
    STK10provided by VGNC
    Official Full Name
    serine/threonine kinase 10provided by VGNC
    Primary source
    VGNC:VGNC:35384
    See related
    BGD:BT26622; Ensembl:ENSBTAG00000017457
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See STK10 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 20 NC_037347.1 (3852216..3974842, complement)

    Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene F-box and WD repeat domain containing 11 Neighboring gene small ribosomal subunit protein eS6-like Neighboring gene laforin Neighboring gene integumentary mucin C.1-like Neighboring gene small ribosomal subunit protein eS1-like Neighboring gene EF-hand calcium binding domain 9 Neighboring gene ubiquitin domain containing 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA-1 clustering and cell adhesion of activated lymphocytes. Endo J, et al. FEBS Lett, 2000 Feb 25. PMID 10692593
    2. Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue. Walter SA, et al. J Biol Chem, 2003 May 16. PMID 12639966
    3. LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation. Belkina NV, et al. Proc Natl Acad Sci U S A, 2009 Mar 24. PMID 19255442, Free PMC Article
    4. Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. Pike AC, et al. EMBO J, 2008 Feb 20. PMID 18239682, Free PMC Article
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 10
    NP_001179556.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192627.1 → NP_001179556.1  serine/threonine-protein kinase 10

      See identical proteins and their annotated locations for NP_001179556.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000020
      UniProtKB/Swiss-Prot
      E1BK52
      UniProtKB/TrEMBL
      A0A3Q1M334
      Related
      ENSBTAP00000064246.1, ENSBTAT00000082906.1
      Conserved Domains (3) summary
      cd06644
      Location:23 → 314
      STKc_STK10; Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase or LOK)
      smart00220
      Location:36 → 294
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12474
      Location:753 → 893
      PKK; Polo kinase kinase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      3852216..3974842 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1BK52.3 GenPept UniProtKB/Swiss-Prot:E1BK52

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