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    GPBAR1 G protein-coupled bile acid receptor 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 317756, updated on 1-Jan-2025

    Summary

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    Official Symbol
    GPBAR1provided by VGNC
    Official Full Name
    G protein-coupled bile acid receptor 1provided by VGNC
    Primary source
    VGNC:VGNC:29521
    See related
    BGD:BT12641; Ensembl:ENSBTAG00000003923
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    TGR5
    Orthologs
    human mouse all
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    Genomic context

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    See GPBAR1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (106290010..106293245)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene chemokine (C-X-C motif) receptor 1 Neighboring gene small nucleolar RNA SNORA42/SNORA80 family Neighboring gene actin related protein 2/3 complex subunit 2 Neighboring gene angio associated migratory cell protein Neighboring gene transmembrane BAX inhibitor motif containing 1 Neighboring gene PNKD metallo-beta-lactamase domain containing

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. The bile acid receptor TGR5 inhibits platelet activation and thrombus formation. Reusswig F, et al. Platelets, 2024 Dec. PMID 38968449
    2. Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells. Kida T, et al. Arterioscler Thromb Vasc Biol, 2013 Jul. PMID 23619297
    3. A G protein-coupled receptor responsive to bile acids. Kawamata Y, et al. J Biol Chem, 2003 Mar 14. PMID 12524422
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The bile acid receptor TGR5 inhibits platelet activation and thrombus formation.
      Title: The bile acid receptor TGR5 inhibits platelet activation and thrombus formation.
    2. TGR5 agonism induces NO production via Akt activation and intracellular Ca(2+) increase in vascular endothelial cells, and this function inhibits monocyte adhesion in response to inflammatory stimuli.
      Title: Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC152072

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled bile acid receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G-protein coupled bile acid receptor 1
    Names
    G protein-coupled receptor TGR5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175049.3 → NP_778219.1  G-protein coupled bile acid receptor 1

      See identical proteins and their annotated locations for NP_778219.1

      Status: PROVISIONAL

      Source sequence(s)
      BC122824
      UniProtKB/Swiss-Prot
      Q0II36, Q862A9
      Conserved Domains (2) summary
      cd14964
      Location:51 → 72
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:28 → 284
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      106290010..106293245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024999245.2 → XP_024855013.1  G-protein coupled bile acid receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q0II36, Q862A9
      Related
      ENSBTAP00000005120.3, ENSBTAT00000005120.5
      Conserved Domains (2) summary
      cd14964
      Location:51 → 72
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:28 → 284
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q862A9.1 GenPept UniProtKB/Swiss-Prot:Q862A9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.