COL4A1 collagen type IV alpha 1 chain [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: COL4A1provided by VGNC
Official Full Name: collagen type IV alpha 1 chainprovided by VGNC
Primary source: VGNC:VGNC:50081
See related: BGD:BT11988; EnsemblRapid:ENSBTAG00070010257
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 52

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	12	NC_037339.1 (84863917..84995777, complement)

Chromosome 12 - NC_037339.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037339.1 Chromosome 12 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High shear stress up-regulates type IV collagen synthesis and down-regulates MMP-2 secretion in endothelial cells.
Title: Laminar high shear stress up-regulates type IV collagen synthesis and down-regulates MMP-2 secretion in endothelium. A quantitative analysis.
alpha1.alpha2 stabilize the noncollagenous domain-1 by noncovalent forces and the absence of Met-Lys cross-links
Title: The alpha1.alpha2 network of collagen IV. Reinforced stabilization of the noncollagenous domain-1 by noncovalent forces and the absence of Met-Lys cross-links.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent conferring tensile strength	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in basement membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of collagen trimer	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: collagen alpha-1(IV) chain

Names: collagen, type IV, alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166511.3 → NP_001159983.2 collagen alpha-1(IV) chain precursor

Status: PROVISIONAL

Source sequence(s)

NKLS02000012

UniProtKB/Swiss-Prot

G1K238, Q7SIB2

Related

ENSBTAP00070013555.1, ENSBTAT00070023037.1

Conserved Domains (2) summary

pfam01391
Location:1103 → 1160

Collagen; Collagen triple helix repeat (20 copies)

pfam01413
Location:1556 → 1666

C4; C-terminal tandem repeated domain in type 4 procollagen