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    ATP2B4 ATPase plasma membrane Ca2+ transporting 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 282146, updated on 1-Jan-2025

    Summary

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    Official Symbol
    ATP2B4provided by VGNC
    Official Full Name
    ATPase plasma membrane Ca2+ transporting 4provided by VGNC
    Primary source
    VGNC:VGNC:97243
    See related
    BGD:BT21263; Ensembl:ENSBTAG00000014059
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    PMCA4
    Orthologs
    human mouse all
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    Genomic context

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    See ATP2B4 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (1398257..1500871)

    Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112441938 Neighboring gene proline and arginine rich end leucine rich repeat protein Neighboring gene opticin Neighboring gene uncharacterized LOC132342430 Neighboring gene lymphocyte transmembrane adaptor 1 Neighboring gene uncharacterized LOC132342431 Neighboring gene zinc finger CCCH-type containing 11A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Switch of PMCA4 splice variants in bovine epididymis results in altered isoform expression during functional sperm maturation. Brandenburger T, et al. J Biol Chem, 2011 Mar 11. PMID 21187283, Free PMC Article
    2. The missing link between thermodynamics and structure in F1-ATPase. Yang W, et al. Proc Natl Acad Sci U S A, 2003 Feb 4. PMID 12552084, Free PMC Article
    3. Arrangement of PMCA4 in bovine sperm membrane fractions. Post H, et al. Int J Androl, 2010 Dec. PMID 20050939
    4. A C-terminal, calmodulin-like regulatory domain from the plasma membrane Ca2+-pumping ATPase. Brandt P, et al. Proc Natl Acad Sci U S A, 1988 May. PMID 2966397, Free PMC Article
    5. Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels. Brandt P, et al. J Biol Chem, 1992 Mar 5. PMID 1531651

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Switch of PMCA4 splice variants in bovine epididymis results in altered isoform expression during functional sperm maturation.
      Title: Switch of PMCA4 splice variants in bovine epididymis results in altered isoform expression during functional sperm maturation.
    2. results indicate possible functional compartmentalization of PMCA in bull sperm membranes and point to a presumptive, interaction partner of Ca(2+)-ATPase and PDC-109.
      Title: Arrangement of PMCA4 in bovine sperm membrane fractions.
    3. thermodynamic analysis of mitochondrial F1 ATPase
      Title: The missing link between thermodynamics and structure in F1-ATPase.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables P-type calcium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables PDZ domain binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    plasma membrane calcium-transporting ATPase 4
    Names
    ATPase, Ca++ transporting, plasma membrane 4 ATP synthase, H+ transporting, mitochondrial F1
    NP_001166065.1
    XP_024831809.1
    XP_024831810.1
    XP_024831814.1
    XP_024831815.1
    XP_024831817.1
    XP_024831819.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172594.1 → NP_001166065.1  plasma membrane calcium-transporting ATPase 4

      See identical proteins and their annotated locations for NP_001166065.1

      Status: PROVISIONAL

      Source sequence(s)
      GU353069
      UniProtKB/TrEMBL
      F1MQ01
      Related
      ENSBTAP00000018688.7, ENSBTAT00000018688.7
      Conserved Domains (7) summary
      TIGR01517
      Location:20 → 1040
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:159 → 442
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:856 → 1034
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:47 → 111
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:1077 → 1139
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:643 → 782
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:503 → 592
      Cation_ATPase; Cation transport ATPase (P-type)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      1398257..1500871
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024976047.2 → XP_024831815.1  plasma membrane calcium-transporting ATPase 4 isoform X3

      UniProtKB/TrEMBL
      F1MQ01
      Conserved Domains (2) summary
      pfam12424
      Location:1089 → 1150
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      cl27747
      Location:20 → 1052
      E1-E2_ATPase; E1-E2 ATPase

    2. XM_024976051.2 → XP_024831819.1  plasma membrane calcium-transporting ATPase 4 isoform X5

      UniProtKB/TrEMBL
      F1MQ01
      Conserved Domains (2) summary
      pfam12424
      Location:1089 → 1171
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      cl27747
      Location:20 → 1052
      E1-E2_ATPase; E1-E2 ATPase

    3. XM_024976041.2 → XP_024831809.1  plasma membrane calcium-transporting ATPase 4 isoform X1

      UniProtKB/Swiss-Prot
      D3K0R5, D3K0R6, Q28059
      UniProtKB/TrEMBL
      F1MQ01
      Conserved Domains (2) summary
      pfam12424
      Location:1089 → 1135
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      cl27747
      Location:20 → 1052
      E1-E2_ATPase; E1-E2 ATPase

    4. XM_024976049.2 → XP_024831817.1  plasma membrane calcium-transporting ATPase 4 isoform X4

      UniProtKB/TrEMBL
      F1MQ01
      Conserved Domains (2) summary
      pfam12424
      Location:1077 → 1138
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      cl27747
      Location:20 → 1040
      E1-E2_ATPase; E1-E2 ATPase

    5. XM_024976046.2 → XP_024831814.1  plasma membrane calcium-transporting ATPase 4 isoform X2

      UniProtKB/TrEMBL
      A0AAF6ZTI3, F1MQ01
      Related
      ENSBTAP00000057551.2, ENSBTAT00000071315.2
      Conserved Domains (2) summary
      pfam12424
      Location:1077 → 1123
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      cl27747
      Location:20 → 1040
      E1-E2_ATPase; E1-E2 ATPase

    6. XM_024976042.2 → XP_024831810.1  plasma membrane calcium-transporting ATPase 4 isoform X1

      UniProtKB/Swiss-Prot
      D3K0R5, D3K0R6, Q28059
      UniProtKB/TrEMBL
      F1MQ01
      Related
      ENSBTAP00000063820.2, ENSBTAT00000079645.2
      Conserved Domains (2) summary
      pfam12424
      Location:1089 → 1135
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      cl27747
      Location:20 → 1052
      E1-E2_ATPase; E1-E2 ATPase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3K0R6.2 GenPept UniProtKB/Swiss-Prot:D3K0R6

    Gene LinkOut

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